Alzheimer’s Patient Reverses Symptoms by Applying Coconut Oil On A Daily Basis

Carolyn, the devoted daughter of an 88-year-old women who has Alzheimer’s recently decided to take charge of her mother’s care. The almost immediate results she saw were drastic and inspiring.

Additionally, the simple change she implemented in her mom’s life is available for any family struggling and suffering from Alzheimer’s to try for themselves.

Her mother spent the last seven years in a nursing home. As the years wore on and her mother’s condition deteriorated, Carolyn started to worry that her mother was being neglected and potentially abused.

Carolyn decided it was time to make a change and take matters into her own hands. She removed her ailing mother and devoted herself to being her mother’s full-time primary caregiver. On February 14, 2016, Carolyn made the hardest and probably the most important decision for her mother and removed her from the toxic nursing home environment and took her home to care for her.

While in the care of the nursing home, Carolyn’s mother was diagnosed with stage 6 Alzheimer’s. Stage 6 is also known as the “severe decline” stage. In stage 6 most patients need help with day-to-day life activities and near constant supervision. For the last two years, Carolyn’s mother struggled to speak and did not remember people, names, faces, and words. Reading had become almost impossible for her mom due to her memory issues. Communication was becoming a real struggle for Carolyn’s mother.

Coconut oil, the wonder drug

Carolyn had read about and was familiar with the benefits of coconut oil. Immediately after her mother’s liberation from the nursing home, Carolyn started liberally applying coconut oil. She would do this twice a day, after bathing in the morning and again at night before bedtime.

Within 5 days she started noticing an immediate and drastic improvement in her mother’s condition. Her mother started remembering people and names she hadn’t in years. She was able to communicate again. Carolyn was amazed when her mother was able to read, out loud, a Bible storybook and only struggled with a couple of words.

Alzheimers and coconut oil, science backs it up

These results may have been shocking, but they are no surprise given the results of a recent Spanish clinical trial. In December 2015, a clinical trial was published on the effects of coconut oil being used to treat patients who have Alzheimer’s.

The study included giving 40 ml, approximately 2.7 tablespoons, of coconut oil a day to one of two control groups. Both control groups were made up of people of varying ages and genders in various stages of Alzheimer’s. One control group received the coconut oil and the other did not.

The study concluded that there was a statistically significant increase in test scores demonstrating improved cognitive status in the control group that received the coconut oil. The study clearly demonstrated the potentially powerful positive effects of coconut oil on patients struggling with Alzheimer’s.

In addition, a US study currently being conducted in Florida is scheduled for publication in late 2016. The health, wellness, and Alzheimer’s communities are eagerly awaiting those results.

Big Pharma doesn’t welcome the idea

The pharmaceutical industry is the one industry that stands to lose the most if the new studies collaborate Spanish study findings. Alzheimer’s disease affects millions of seniors and is a rapidly increasing disease. Pharmaceutical companies have been working for years to develop a vaccine but to date have come up empty handed. Pharmaceutical companies may be left out in the cold if the connection between coconut oil and cognitive ability increase in Alzheimer patients is proven.

For Carolyn and her mother there is no doubt that coconut oil has made a huge impact in their daily lives. Carolyn and her mother are enjoying this additional time together, their newfound freedom, and their ability to communicate with one another.

Sources:      

http://healthimpactnews.com/2016/88-year-old-woman-recovering-from-alzheimers-and-diabetes-using-coconut-oil/

http://healthimpactnews.com/2015/study-coconut-oil-improves-cognitive-functioning-in-alzheimers-patients/

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Alzheimer’s Patient Reverses Symptoms by Applying Coconut Oil On A Daily Basis

Caloric Restriction: Understanding the Genetic Basis and How Alpha Lipoic Acid Fits the Picture.

Research on caloric restriction (CR) covers a span of 80 years and study results have fluctuated between negative, to sometimes positive, to consistently positive under the right conditions, and presently to positive but of little value beyond a normal caloric intake. Recent research, in addition to confirming the value of CR on health-span and possibly longevity, has identified the genetic pathways that are activated in CR, and opened the door to interventions such as alpha lipoic acid that might mimic the positive effects of CR, without the difficulty of adhering to a low calorie diet. The most recent research on CR has highlighted the importance of the macronutrient ratio in achieving positive health effects, particularly the ratio of protein to carbohydrate.

EARLY CR STUDIES:

The first study on CR was conducted in 1935, but was based on societal problems with malnutrition, and had nothing to do with possible beneficial effects on health and aging. To the contrary, the study demonstrated retarded growth during development, poor health and a shorter lifespan. Some years later, a study was performed in rats by McKay et. al., that only restricted calories, but still provided the vitamins, minerals and micronutrients required to maintain health. Like the earlier study, developmental growth was retarded, but the animals experienced a considerably longer lifespan. During this time period, researchers concluded that the beneficial effects of CR are the result of delayed developmental growth. This conclusion was a clue to the mechanism behind the health benefits of CR, but was later proven incorrect.

Studies in the 1950’s and 1960’s demonstrated that intermittent fasting was as effective as chronic CR, providing a more user-friendly way to achieve the health benefits of CR. Considerable research, with varying results continued for several decades, but the real breakthrough came in 1996 in research that was performed on simple animal models (worms and flies) that elucidated the molecular pathways involved in CR.

CR METABOLIC PATHWAYS:

It comes as no surprise that humans have a gene-based survival system to prolong survival during periods of prolonged famine, and that this system serves as a sensor for nutrient and energy levels, and a regulator of biomass formation. What is surprising is the fact that regulation of this system can have long-term beneficial effects on health and possibly on lifespan. The discovery of this system had it’s origins in an antifungal/immunosuppressant substance that was isolated from a soil sample from the Easter Islands (Rapa Nui). It was named Rapamycin in reference to the place it was discovered. Work on microorganism resistance to Rapamycin led to the later discovery in yeast that Rapamycin inhibits a gene that produces a serine/threonine protein called mTOR (mammalian target of rapamycin), and that like CR, Rapamycin extended lifespan.

The key regulator in this metabolic pathway is a complex of mTOR and co-factors that is identified as mTORC1. mTORC1 is a signaling hub that integrates nutrient and energy signaling with growth factor signaling. Generally mTORC1 stimulates protein synthesis and anabolic growth and inhibits autophagy. Conversely, CR and Rapamycin inhibit mTORC1 which reduces protein formation, and ATP formation, and increases autophagy.

mTORC1 is a complex system that stimulates numerous downstream processes including messenger RNA translation and the transcription factor C/EBPbeta-LIP. LIP is a protein that binds to DNA metabolic regulating sites. The LIP protein can be suppressed by removing an upstream regulatory element (uORF), which produces an effect equivalent to CR or Rapamycin. As is usually the case in this type of situation, developing a drug that inhibits uORF or another critical step in the mTORC1 pathway could theoretically lead to a drug to extend health-span and lifespan.

PHARMACOLOGIC INTERVENTION IN mTORC1 PATHWAY:

The scientific community and the media are conditioned to judge the value of a research finding by the possibility of developing a drug to achieve a therapeutic objective. History, while uniformly disregarded, has shown that drugs designed to block physiological processes rarely act on only the process being targeted. The result is an effective drug, with serious side effects that emerge during clinical trials or after the drug is marketed. To my amazement, society is becoming more accepting of these serious side effects as reflected in the marketing of most biologics. I believe that Rapamycin fits this description as a drug to combat aging. Rapamycin clearly inhibits mTORC1, but has many serious side effects that make it unsuitable for widespread chronic use. This hasn’t stopped the media from touting Rapamycin as the Fountain of Youth drug, and I sense that drug companies will eventually promote the drug for this use and attempt to justify the side effects as reasonable vs. the benefits.

There are many naturally-occurring substances that have epigenetic effects similar to the actions of more powerful drugs, and generally without the serious side effects. One such substance is the widely researched and less widely used alpha lipoic acid. In addition to its favorable effects on oxidative stress and diabetic neuropathy, more recent research has recognized the multi-functional properties of alpha lipoic acid, with particular emphasis on the stimulation of AMPk and the corresponding inhibition of mTORC1 activity. As described in the research reports referenced below, alpha lipoic acid, along with other energy restriction mimetics (resveratrol, rapamycin, metformin and spermidine) stimulates formation of kinase activated AMP, that in turn signals that the cell is in an energy restricted state, and mTORC1 is inhibited. The paper by Nikolai et.al. states that these CR mimetics can have serious side effects and have not been proven safe for long-term use. Contrary to this position it should be noted that alpha lipoic acid has been studied extensively for several decades and has been cited in almost 5000 scientific papers, the vast majority of which report beneficial effects. It is true that alpha lipoic acid has not been subjected to extensive controlled, double-blind studies in humans, but it is commonly used by many health conscious consumers, with no reports of adverse events. Because alpha lipoic acid is a naturally occurring substance that cannot be patented, it is unlikely that funding will be made available for controlled clinical studies or education of the public regarding its many benefits.

PROTEIN: The FINAL NAIL in the CR COFFIN:

Research on CR has focused attention on all of the factors in the design of studies that have had unexpected outcomes. One of these factors was the macronutrient composition used in the study, with particular attention to the ratio of protein to carbohydrate. Using a research tool designated the Geometric Framework nutritional modeling method, researchers Raubenheimer and Simpson (Sydney, Australia), found that diets that were low in protein and high in carbohydrates produced a health-span comparable to CR. A low protein diet was defined as <5% calories from protein, a moderate protein diet as 10% – 20%, and a high protein diet as >20%. Disease and mortality was surprisingly high for the high protein diet, but ameliorated by substituting plant protein for animal protein. This effect was observed in persons under age 65, but the reverse was true for people over age 65, who had higher disease and mortality with a low protein diet and better health and longevity with a high protein diet. The mechanism behind the negative effects of a high protein diet appear to be related to stimulation of the mTORC1 pathway by nutrient sensing of the high availability of amino acids in the cells. It isn’t clear why this protein effect reverses at age 65, but presumably has to do with the accelerated loss of muscle mass with aging, which would be exacerbated with inhibition of the mTORC1 pathway.

CONCLUSION:

It is well-established that under the right conditions, CR is an effective way to lose body mass, extend health-span and possibly extend lifespan. Research studies on CR have contributed to the discovery and understanding of the mTORC1 pathway, which is the major regulator of metabolic activity in humans. While CR is beneficial in itself in reducing chronic disease, it is a difficult regimen to follow and certainly not in sync with modern lifestyles. CR research has led to the discovery that equivalent beneficial effects can be realized with a normal diet, provided that the ratio of protein and carbohydrate are optimized for age. Elucidation of the mTORC1 pathway has also opened the door to user-friendly means of inhibiting the mTORC1 pathway through design of drugs that block or inhibit steps in the regulatory process, or preferentially the application of naturally-occurring molecules such as alpha lipoic acid that stimulate formation of AMPk and down-regulation of mTORC1.

REFERENCES:

1. The ratio of macro-nutrients, not caloric intake, dictates cardiometabolic health, aging, and longevity in ad libitum fed mice.  Solon-Biet, SM  et. al., Cell Metab. 2014 Mar 4: 19 (3); 418-430.


2. Alpha-Lipoic Acid Supplementation Reduces mTORC1 Signaling in Skeletal Muscle from High Fat Fed, Obese Zucker Rats.  Zhuyun Li, Cory M. Dungan, Bradley Carrier, Todd C. Rideout, David L. Williamson.  Lipids. Dec 2014, Volume 49, Issue 12, pp 1193-1201.


3. Energy restriction and potential energy restriction mimetics.  Nikolai, S et. al., Nutr Res Rev. 2015 Dec;28(2):100-120. Epub 2015 Sep 22.

Caloric Restriction: Understanding the Genetic Basis and How Alpha Lipoic Acid Fits the Picture.

More powerful Genetic Basis For Schizophrenia, Landmark Study Finds

Far more than 80 newly identified genes could area people at danger for developing schizophrenia, strengthening the evidence for a biologic basis for a disorder that has an effect on nearly 24 million people or 1 % globally, according to the benefits of a new research.

The examine, as anticipated, confirmed that genes involving dopamine regulation are concerned in schizophrenia, but also found that genes tied to the immune system and also relevant to smoking have been linked as well.

The exact romantic relationship of the newly recognized genes areas relevance on the want for further function to uncover the sudden findings, particularly genes linked with smoking. It unclear whether smoking genuinely increases threat, but if confirmed, smoking cessation could be incorporated as portion of a risk assessment and evaluation.

The findings of the research were published July 22 in the Journal, Nature.

English: Image displaying brain locations much more active in controls than in schizophrenia sufferers throughout a functioning memory task in the course of a fMRI study. Two brain slices are proven. (Photo credit score: Wikipedia)

Schizophrenia, now identified to have a genetic basis, leads to a delusional state characterized by abnormal perceptions, including agitation, paranoia, as well as hearing voices, which can also lead to violent habits.

In the previous, there had been controversy amid professionals about the precise leads to of the mental sickness, with some not recognizing schizophrenia as a illness at all, and others unclear regardless of whether it had its origins from traumatic events and experiences in childhood, or, in reality, was biologically based.  About thirty genes had been imagined to be responsible for the growth of schizophrenia, with suspicion of environmental factors contributing to its onset.

With this landmark study–lasting 7 years, involving far more than 80,000 genetic samples and evaluating men and women with and without the disease–it now turns into evident that there is stronger and far more convincing proof that the presence and activity of distinct genes can account for individuals with the symptoms of schizophrenia.

The historic examine across 35 countries–the biggest to date of people living with schizophrenia–examined the genetic make up of far more than 35,000 folks living with the problem, compared to 110,000 with out the disorder.

The research utilized a method recognized as genome wide association, a method comparing the sequenced genomes of those affected by the situation to individuals unaffected.  The differences in the genomes of those with the illness may well then offer attainable clues to the origins of schizophrenia, which could be potential  targets for drug therapy.

The research identified much more than a hundred genes which place people at a higher risk of building schizophrenia, of which 83 have in no way recognized in the past.  The bulk of the newly identified genes affect the relay of messages by way of chemical signaling as a measure of plasticity, but some have been also mentioned to be integral in the immune system and the potential to battle off condition.

Interestingly, earlier analysis has currently uncovered information indicating individuals with schizophrenia have indications of inflammation based on specific blood markers called cytokines. Of note, one particular report has recommended that relatives of persons with schizophrenia have up to a 45 % increased possibilities of building schizophrenia.  The findings from this examine now confirm and support the connection with the immune method.

Of note, there have not been any groundbreaking advances in the pharmacologic therapy of schizophrenia because the drug thorazine was 1st utilized in the late 1950’s.  The target of thorazine, the dopamine pathway, has been the basis for every single drug  developed for treating the condition.

Dr. Kyle Lapidus, Assistant Professor of Psychiatry and Neuroscience at the Icahn School of Medicine, Mount Sinai Health-related Center in New York City, explains that pharmacologic advances have not been a major part of  modifications in approach to patients with schizophrenia considering that the 1960s.

“Clozapine is the most distinct of presently approved medicines for schizophrenia,” said Lapidus. “Although other medication have been accepted much more recently, these do not target novel mechanisms or demonstrate superior efficacy.”

With the discovery of additional genes now implicated in the advancement of schizophrenia, numerous scientists are hopeful that there will be further opportunities to determine medicines or biologic agents to intervene in the pathways top to abnormal brain chemistry or signaling as element of the disorder.

More powerful Genetic Basis For Schizophrenia, Landmark Study Finds

British Lung Basis: smoking in cars "could lead to meningitis" in kids

The Commons will vote on whether to give the well being secretary the power to impose a ban on smoking in vehicles, despite the opposition of some MPs like members of the Cabinet.

Steven Wibberley from the British Lung Foundation explained the overall health implications of smoking in automobiles.

“Simply because it truly is an enclosed environment, it concentrates the smoke and the toxins in that smoke and due to the fact children have got modest underdeveloped lungs, that has a true impact on their overall health.”

“It leads to factors like asthma, chest infections, ear infections, but also even factors like meningitis.”

Downing Street has confirmed that Prime Minister would miss the vote, as he is staying in the South West overnight to pay a visit to locations impacted by flooding, but indicated that he believes “the time has come” for a ban on smoking in vehicles containing young children.

British Lung Basis: smoking in cars "could lead to meningitis" in kids

The Brain And Conduct Investigation Basis: Producing A Big difference In Mental Overall health Study

On January 29, 2014, The Brain and Habits Analysis Basis, an organization which money cutting edge mental overall health investigation, announced important discoveries of 2013 funded by its NARSAD grants.

NARSAD is an acronym for the National Alliance for Analysis on Schizophrenia and Depression, the former identify for the now Brain and Behavior Analysis Foundation.

In accordance to Jeffrey Borenstein, M.D., President and CEO of the Brain and Behavior Analysis Basis, NARSAD grants support to fund investigation that gives new insight into the mysteries of the brain and prospective therapies for folks with depression, anxiousness, schizophrenia, PTSD and panic disorder.

NARSAD grants are targeted on three particular regions of attacking mental illness: standard investigation, new technologies, and subsequent generation therapies. Different amounts of economic assistance are supplied ranging from NARSAD Youthful Investigator Grants ($ 30,000/12 months), NARSAD Independent Investigator Grants  ($ 50,000/12 months) to NARSAD Distinguished Investigator Grants (a hundred,000/yr).

As Borenstein explains, the discoveries in standard analysis, new technology, next generation therapies and early intervention ranged from findings exhibiting the brain adds one,400 new neurons a day all through a person’s lifetime to the identification of brain activity that predicts regardless of whether people with serious depression will reply far better to antidepressants or psychotherapy.

The Brain &amp Habits Study Foundation, which funded 225 NARSAD Grants with $ 17 million in 2013, raises money to fund cutting-edge research for the comprehending, early detection, treatment method, prevention and remedy of psychological illness. It has awarded more than $ 300 million in NARSAD Research Grants to much more than 3,700 scientists about the world given that 1987. Since its inception, the Basis has been supported by private donations.

“We are getting into the golden age of brain research,” said Borenstein, noting that 2013 was a 12 months of extremely important advances.

“The best 10 findings of 2013”, Borenstein proclaims, “highlight the sort of scientific function that will support us recognize, treat and cure the psychological illnesses that have an effect on a single in four individuals.”

The mission at the Brain and Conduct Study Basis, however, is very exclusive in relation to funding psychological health analysis.

“We are in a position to fund cutting edge study that the government wouldn’t fund due to the fact typically they [the government] will fund research that already has some level of proof in location,” delivers Borenstein.

“We are ready to fund the preliminary perform that then permits our scientists that we fund to go on and get further federal funding”, explains Borenstein.  “The government is considerably more risk averse so the chance for actual advances comes from the sort of funding that we give.”

In accordance to Borenstein, right after monitoring individuals investigators who have achieved funding through the Brain and Behavior Investigation Foundation, “for every dollar that we have supplied in funding, they have eventually received on typical of 10 dollars from governmental funding subsequently.

As Borenstein sums up, “Because federal funding for study is steadily declining, personal funding is necessary to drive the type of substantial chance, large reward research that alterations lives.”

Borenstein theorizes that there has been a decline in federal funding for mental well being analysis in essence since “there is nevertheless prejudice towards psychological health issues, particularly how it is portrayed in the press making a stigma–which in some approaches impacts funding for psychological health”.

“The overall economic scenario and government tightening combine to make private funding far more crucial than ever”, additional Borenstein. “The paradox is that we are truly at a level in time of great opportunity.”

Borenstein concludes that “if we have been to then accelerate the amount of funding it would tremendously advance exactly where we are in terms of remedy for these conditions that impact so numerous people. “Everybody has a loved one particular or pal affected by a single of these situations.”

The Brain And Conduct Investigation Basis: Producing A Big difference In Mental Overall health Study