humans etiketine sahip kayıtlar gösteriliyor. Tüm kayıtları göster
humans etiketine sahip kayıtlar gösteriliyor. Tüm kayıtları göster

8 Ocak 2017 Pazar

How colour-changing cats might warn future humans of radioactive waste

Plans for a new fleet of UK nuclear power plants are under way. Last month, for example, Hitachi and the Japanese government confirmed a plan to construct 5.4 gigawatts of generating capacity at UK sites. But what about the waste? And what happens when, in thousands of years, our descendants – who may not read any current human language – find a store, and put themselves in danger?


A panel of scientists and linguists asked this question in 1981 when the US Department of Energy commissioned them to find a method of ensuring that whatever is left of humanity in 10,000 years’ time is warned off the sites we’ve been filling with radioactive sludge.


The panel reasoned that since few people can read texts that are only 1,000 years old, written warnings guaranteed to be understood by future humanity could be difficult to create.


The answer may lie in “nuclear semiotics” – future-proof signs. Other options include hostile architecture, obelisks – or cats.


In 1984, writer Françoise Bastide and semiotician Paolo Fabbri suggested the answer could lie in breeding animals that “react with discoloration of the skin when exposed” to radiation. “[Their] role as a detector of radiation should be anchored in cultural tradition by introducing a suitable name (eg, ‘ray cat’).”


In short: cats that turn, say, green when near radioactive material. A legend, passed on through the millennia, would trigger a response in humans to get out as soon as possible.


The idea has recently gained fresh traction: the Ray Cat Solution movement, formed in 2015, is working to “insert ray cats into the cultural vocabulary”. They say it may be possible to harness some animals’ innate capacity to become fluorescent, or to absorb and emit light – but cats don’t have the physiology to do that. Another way would be to engineer cats to glow using enzyme interaction – a mechanism used to study cellular activity. Far fetched, but it could just work.



How colour-changing cats might warn future humans of radioactive waste

16 Temmuz 2014 Çarşamba

Do Humans Reside As well Prolonged?

“Public health fundamentally changed what it means to be human,” S. Jay Olashansky argues in a short video explaining the jump in human life expectancy in the mid-19th Century. For more than 200,000 years, most humans died by 30 and infant mortality was endemic. But over the last two centuries human life expectancy has more than doubled. In the last century the average American life expectancy rose from 47 to 78, largely attributable to improved understanding of personal hygiene, effective treatments for childhood diseases, and shifts toward safer working spaces.


If you accept that it doesn’t inherently mean anything to be human, the extension of life expectancy has expanded the existential vacuum in which human imagination has begun to invent many different meanings for itself with increasingly industrial efficiency. Paradoxically, this drive to fundamentally change what it means to be human has also become a catalyst for deepening categorical differences between people and rationalizing a menagerie of deprivations by making them seem like the statistical inevitabilities of progress.  The first fissures of this obsolescence have become visible in the recent distinctions in life expectancy between rich and poor. In the last two decades the life expectancy of the poor has begun falling.Today, college educated white men live to 80, while those who failed to graduate high school live to 67. A white male without a high school diploma will die three years earlier today than he would have two decades ago, according to a 2012 report from Health Affairs. White female high school dropouts will die five years earlier than their counterparts would have in the early 1990s.


The irony of increased life spans is that the majority of that found time ends up being used for work, the one social burden we keep expecting technology to deliver us from. The more time they spend occupying on a job, the more finicky and competitive the labor market becomes, making it difficult it becomes for the young and poor to break through the fog of nepotism and prejudicial eligibility requirements. “The succession of generations could be obstructed by a glut of the able,” bioethicist Leon Kass wrote in a report on aging for The President’s Council on Bioethics. “The old might think less of preparing their replacements, and the young could see before them only layers of their elders blocking the path, and no great reason to hurry in building families or careers-remaining functionally immature ‘young adults’ for decades, neither willing nor able to step into the shoes of their mothers and fathers.”


This widening differential adds new pressure to America’s already strained political and economic structures. According to George Dranitsaris, a healthcare consultant and research scientist, the ideal ratio for an economy is four active workers for every retired person, but this has already dropped to 3.5 workers for every retiree, and could reach three to one within a decade. “As people live longer the data shows they put greater strain on resources,” he told me. “There certainly won’t be enough people working for governments to pay to look after elderly people who won’t be working, especially for countries like the United States, which has a pretty generous social security system.”


Get back to work. Image via Creative Commons/Victor Casale.

Get back to work. Image via Creative Commons/Victor Casale.



Meanwhile, the quest to further lengthen one’s life has created a new cottage industry of speculative research into technology that could further distance the beneficiaries of furthered human life expectancy technology from those whose share of those gains is dwindling. And now that most of the old causes of mortality attributed to pathogens and environmental factors have been theoretically resolved, the project of extending lifespans appears to be reaching a fundamental limit within the body itself. The most basic determinant of aging is thought to be the natural limit on somatic cell division, called the Hayflick Limit after UCSF evolutionary biologist Leonard Hayflick. Cell division that drives human life eventually comes to an end, either because the genetic material in them becomes progressively unstable after each division, or because the mitochondria that provide energy for division eventually oxidize


Ray Kurzweill is perhaps the most famous immortalist, insisting that when described as a series of molecular mechanisms there is no reason to believe death can’t be stopped or reversed, something that would only contribute to overall human productivity. “Our initial reaction to hearing that someone has died is a profound loss of knowledge and skill and talents and relationships,” he said in an interview with Wired. “It’s not the case that there are only a fixed number of positions, and if old people don’t die off, there’s no room for young people to come up with new ideas, because we’re constantly expanding knowledge. Larry Page and Sergey Brin didn’t displace anybody– they created a whole new field.”


Absent from these claims are any practical ideas about how the young should be accommodated. The transition to a knowledge economy as embodied by Page and Brin depends on its ability to command greater profits with significantly smaller operational costs than preceding industries, something that only intensifies the competitive pressure on the young and in-need and worsens their chances at a longer life. Google earned more than twice the net income of General Motors in 2013, and yet it employed less than one-fourth as many people. Apple earns more than six times as much net income than GM and employs less than half as many people. These are economic structures of disenfranchisement, and using the profits sprung from them to rationalize an industry of speculative longevity research is self-abnegation imposed from above.


The conception of death as tragic is, likewise, not wrong but incomplete. Death is also mundane, peaceful, relieving, and in some cases an act of definitively human generosity. Whatever meaning there is in humanity, it lies not in the capacity of the individual to prolong its own encounter with the world, but in the overwhelming number of perpetually regenerating individuals who thrive when driven toward interdependence rather than categorical fragmentation.


Instead of using technology to eliminate death, we might use it to better be able to manage its inevitability for the benefit of the community instead of the individual ego that can’t accept its end. Earlier this year a 70 year-old New York woman, Sandy Bem, invited her family to her home and killed herself. Five years earlier she’d been diagnosed with Alzheimer’s disease and decided that when she reached the point where she could no longer care for herself she would take her own life. “She talked about it a lot,” her daughter Emily told NPR. “It was just sort of sprinkled throughout life. She would often say, ‘Well, in two years I’m going to do it,’ and then two years would go by and she hadn’t declined enough where it warranted it. Then she would say, ‘Well, two more years.’”


After she turned 70, Bem determined that her time had come, there weren’t any remaining years to be bargained for. So she called her family over one last time. They took a long walk, watched Mary Poppins together spoke among themselves, and then she went into her bedroom and asked for her husband of 49 years to come lie beside her in bed after she’d taken a fatal drug overdose, self-administered to avoid New York’s laws against assisted suicide. And while the event was unquestionably somber Bem’s daughter says she wouldn’t have had it any other way.  “It made it less like a grieving process and less like a sort of horrible thing that had happened,” she said, “and more like something that made sense and felt right and actually had some joy to it in its own way.” One of the few studies of the effects of prepared suicide on surviving family members found that in some ways it left loved ones slightly better prepared to deal with the grieving process.


To the victor go the spoils. Image via Creative Commons/Ralph Aichinger.

To the victor go the spoils. Image via Creative Commons/Ralph Aichinger.



That we have so effectively insulated ourselves from death should not be mistaken for evidence that death is, or should be, eradicable. The quest for a long life is a distraction of luxury, the uneven distribution of which points to the ways in which our collective schemes for utopian self-improvement smuggle the violent social divisions of our present into each subsequent generation, building up an industry of normalized depravity with empirical battlements of objective data.


There is no secret to immortality. We live in a borderless expanse of immortal matter, in which our alien plumes of consciousness are the anomaly. Everything in us is already bound to an immortal existence save the unreliable ghost of our egos. We will not have solved the problem of death by postponing our ego’s confrontation with it, nor is there a coherent explanation for why death of individual consciousness is a problem. Death produces heartbreak and sorrow, which weigh down life for those left behind, but like hunger sorrow is a need expressed through inarticulate urges, something that should point us to structures of community in the way hunger points us toward food. We don’t answer the need by making its sensory signals imperceptible.


The longer we drive ourselves to live, the more we make a taboo of death, narrowing our ability to think about it in personal, plausible terms. Instead, it becomes a phantom, symbolic of an subjective dread that makes every form of struggle to outpace it seem noble and rational. We define ourselves by the lengths we are willing to go to be anything other than ourselves, and the basis of all such efforts require a baseline population against which to measure our progress, people whose suffering becomes proof that we were right to be afraid and should press onward at any cost, until what it fundamentally means to be human can be claimed as a product of our own making, the distribution of which will depend on the imperial generosity of those who invented it.


Mastering control of the biological arc of death does not mean people will no longer die, but only that some people will have successfully dissociated themselves from all the rest. And as our lives continue to grow longer for no meaningful reason, it’s possible to see how far apart we’ve already grown.



Do Humans Reside As well Prolonged?

4 Mayıs 2014 Pazar

Youthful mice blood may hold crucial to age-associated diseases in humans - video






New scientific studies propose blood from young mice has rejuvenating results on older mice, and might lead to new therapeutic approaches to age-associated conditions in people. This distinct development element identified in younger mice’s blood, known as GDF11, helps to regulate the aging process in brain and muscle tissue. The research were primarily based on procedures in which one youthful and outdated mouse are joined together by a single circulatory technique







Youthful mice blood may hold crucial to age-associated diseases in humans - video

26 Ocak 2014 Pazar

The Era Of Genetically-Altered Humans Could Begin This Yr

By the middle of 2014, the likelihood of altering DNA to generate a genetically-modified human could move from science fiction to science actuality.  Sometime prior to July, the Uk parliament is probably to vote on whether a new kind of in vitro fertilization (IVF)—involving DNA from 3 parents—becomes legally offered to couples. If it passes, the law would be the first to allow pre-birth human-DNA modification, and another door to the potential will open.


The procedure focuses on changing mitochondrial DNA (mtDNA) as a indicates to steer clear of certain cell mutations. Mitochondria are the power plants of human cells that convert energy from food into what our cells want to perform, and they carry their very own DNA apart from the nuclear DNA in our chromosomes where most of our genetic data is stored. Only the mother passes on mtDNA to the kid, and it sometimes contains mutations leading to significant issues.



Baby Bath

Baby Bath (Photo credit score: Kyle and Kelly Adams)




According to the journal Nature, an estimated one in 5,000-10,000 individuals carry mtDNA with mutations top to blindness, diabetes, dementia, epilepsy and a number of other impairments (the equivalent of one,000 – 4,000 kids born each and every year in the U.S.). Some of the mutations lead to fatal diseases, like Leigh Syndrome, a unusual neurological disorder that emerges in infancy and progressively destroys the capability to think and move.


By combining regular mitochondrial DNA from a donor with the nucleus from a prospective mother’s egg, the newborn is theoretically cost-free from mutations that would eventually lead to one or far more of these ailments. Although never ever tried in people (human cell analysis on mtDNA has so far been confined to the lab), researchers have effectively examined the method in rhesus monkeys.


Final March, the United kingdom Human Fertilization and Embryology Authority wrapped up a lengthy research of security and ethical considerations and suggested parliament to approve the procedure in people. According to New Scientist magazine, parliament is very likely to vote on the procedure by July of this 12 months. If the method overcomes that hurdle, it will nonetheless get several months for it to pass into law, but the preliminary vote will let researchers to start recruiting couples for the first human mtDNA replacement trials.


The U.S. is not almost as close to approving mtDNA substitute as the United kingdom seems poised to do the U.S. Food and Drug Administration will commence reviewing the information in earnest in February.  Between the concerns on the table is no matter whether the mtDNA donor mom could be considered a real “co-parent” of the child, and if so, can she claim parental rights?


Even although the donor would be contributing just .one percent of the child’s complete DNA (according to the New Scientist report), we don’t as yet have a DNA benchmark to judge the problem. Who is to say what percentage of a person’s DNA have to come from another human to constitute biological parenthood?


Other scientists have raised considerations about the compatibility of donor mtDNA with the host nucleus and think the push to legalize human trials is premature. By artificially separating mtDNA from the nucleus, these researchers argue, we might be brief-circuiting levels of genetic communication that we’re only beginning to entirely recognize.


These are but two of numerous problems that this procedure will surface in the coming months. 1 thing is specific: we’re rapidly moving into new and deeper waters, and possibilities are we’re going to need to have a bigger boat.


You can find David DiSalvo on Twitter @neuronarrative and at his internet site, The Every day Brain. His newest book is Brain Changer: How Harnessing Your Brain’s Energy To Adapt Can Alter Your Existence.



The Era Of Genetically-Altered Humans Could Begin This Yr

30 Aralık 2013 Pazartesi

Cold reality: humans aren"t as resilient as Exmoor ponies | George Monbiot

Exmoor Pony foal

‘I believed of Exmoor ponies and the way they stand with their backs to the rain until it passes. If they could do it, so could I.’ Photograph: Alamy




It was a gorgeous morning, a Saturday in October, and I was obtaining tea with my subsequent-door neighbour. We started speaking – for this was almost 20 many years ago – about the street the government meant to create all around the town of Newbury, some thirty miles away. When the machinery moved in we planned to join the protests. Men and women had been presently starting up to create platforms in the trees. “Let us go down and consider a search.”


A train was due to depart in half an hour. We threw sleeping bags and warm outfits into our pannier bags, jumped on our bikes and sprinted to the station. We arrived just as the train was leaving. “Why do not we just cycle there?”


We had missed our breakfast and had no foods or water, but there have been bound to be stores or pubs along the way. We would maintain off the roads as considerably as attainable, following bridleways and footpaths.


At initial we sailed along, feeling buoyant and free of charge. It was one of those autumn days in which the sky appeared cleaner and brighter than at any time for the duration of the summer season. Then the paths started cutting across fields which had recently been ploughed, and our urban bikes grew to become snarled up with mud. A pregnant grey cloud blotted out the sun and hail started pelting down. This was the stage at which my pal discovered that his raincoat, which had been clipped to the prime of his bike rack, had fallen off. He went back to search for it. I made the decision to wait in the discipline.


The hail soon turned to rain. I was even now steamed up, so it felt refreshing as it soaked into my T-shirt. Soon after a while I began to come to feel a tiny cold. But – and this is the nail of idiocy on which the story hangs – I imagined of Exmoor ponies and the way they stand with their backs to the rain until it passes. If they could do it, so could I.


By the time my friend returned I was shivering. But I was reluctant to alter my outfits, as I knew we would quickly get sizzling again crossing the fields. The rain had ceased, but now our bikes slithered across the moist path. By the time we hit firmer ground I was extremely hungry. I was stunned to discover that I was nevertheless shivering.


We rode more than the downs to a village in which, we have been sure, there would be a shop. There wasn’t. The pub was shut. No matter, we would eat in Newbury. By the time we reached a prolonged slope major up to the Ridgeway – the neolithic path that traverses southern England – I had ceased to really feel both cold or hungry. Thoughts over matter, I informed myself I had triumphed more than discomfort.


But there was something incorrect with my bicycle. The wheels would not go round. I turned the bike in excess of and identified to my surprise that they spun freely. I started out pushing it up the hill, but once more it seemed to be snagged. My friend gallantly provided to swap. But there was anything incorrect with his bicycle as well. It felt absurdly hefty, and the wheels also seemed to be jammed.


We remounted when we reached the Ridgeway. Even on the level track I could scarcely force the pedals round. We reached the metalled street, and I sat like a pudding as we freewheeled down a shallow slope. Then I gradually toppled off the bike. I stumbled backwards into the hedge beside the road, where I lay spreadeagled.


“Are you all right?” “I’ve in no way felt far better. But I cannot truly move,” I stated. I felt as if I were lying in a warm bath. I could move my mouth and eyes but little else. I had never experienced this kind of deep peace.


“Um, I believe we need to get some help,” my good friend ventured. “No actually, I am fine.” My friend, who is not renowned for his assertiveness, stood by the street, half raising a hand to the passing site visitors: “Um, excuse me … Would you mind …” I watched with amusement as the cars whizzed previous. Then a big black point stopped and a blond giant stepped out. He was dressed in black, he had a crewcut and muscle tissue everywhere. He brushed past my pal and seized me by the shoulders.


“What is your name?” “George.” “What is your name?” “I just informed you – George.” “What is your title?!” Who was this rude guy, I wondered, and why could not he just depart me alone? He turned to my pal. “What have you got in your bags?” “Um, sleeping bags, coats.” “You happen to be carrying sleeping bags and he’s – fuck, I have witnessed it all now.”


He pulled out a sleeping bag, lifted me up as if I had been a cat and dropped me into it. “What’s your name?” “I just advised you.” “Shut up! What’s your identify?” He walked into the street, his great hands raised to the visitors. The first auto stopped. “Chocolate, sweets, what ever you’ve acquired.” Terrified, the girl in the car scrabbled in her bag, then handed him a bar of chocolate.


He returned to me. “This is very variety of you, but I am really all proper actually.” “Shut up! What is your title?” He started feeding me the chocolate. It was plainly safer to obey than to resist this madman, so I ate it. He named the ambulance. “Truly, there is no need to have …” He stopped far more autos, forcing them to disgorge a pile of sweets and chocolates. “I never have a lot of a sweet tooth to be honest…” “Shut up! What is your identify?”


The ambulance arrived. They wrapped me in a room blanket and took my temperature. They appeared to be creating a terrible fuss about practically nothing. The black vehicle drove away. They place the sirens on and stored making use of the thermometer: my temperature had fallen, I was later on told, to half a degree above the level at which they would have misplaced me.


In hospital the nurse told me I would need to have “the total treatment method”. “No. What?” “Sizzling chocolate and toast and honey.” Half an hour following I had arrived, I sat up and swung my legs off the bed: out of the blue fit and well and buzzing with sugar. It took me a number of hours to realise that the blond giant (we guessed he was an army paramedic) had saved my lifestyle.




Cold reality: humans aren"t as resilient as Exmoor ponies | George Monbiot