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10 Mayıs 2017 Çarşamba

Gluten-free diet carries increased obesity risk, warn experts

Substituting everyday staples with gluten-free foods could increase the risk of obesity, experts have warned, after finding that such products often contain higher levels of fats than the food they aim to replace.


A gluten-free diet is essential to those with coeliac disease – an auto-immune condition that is thought to affect 1% of Europeans – while the regime is also proving increasingly popular among those without the disease. But while a host of gluten-free products are on the market, researchers have said they have a very different nutritional make-up to conventional staples.


“There is very little [consumers] can do about it,” said Joaquim Calvo Lerma of the Instituto de Investigación Sanitaria La Fe in Spain and co-author of the research. “Unfortunately consumers can [only] eat what is available on the market.”


Calvo Lerma’s warning comes after he and his and colleagues compared 655 conventional food products to 654 gluten-free alternatives across 14 food groups including breads, pasta, breakfast cereals, biscuits and even ready meals, covering a range of brands.


The results – presented at the annual meeting of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition – reveal that, overall, gluten-free products were more energy-dense than their conventional counterparts.


The team found that, on average, gluten-free bread loaves had more than twice the fat of conventional loaves, while gluten-free breads in general had two to three times less protein than conventional products. Gluten-free biscuits were also found to be lower in protein but higher in fat, while gluten-free pasta had lower levels of sugar and just half of the protein of standard pasta.


Calvo Lerma warned that gluten-free foods could be contributing to an increased risk of obesity, particularly among children who are more likely to eat products like biscuits and breakfast cereals. He urged consumers to compare gluten-free products across brands to find those with the lowest fat content.


Calvo Lerma also called on manufacturers to innovate. “It is the responsibility of the food industry to produce these type of gluten-free products from other materials that are much healthier or have a [more] enhanced nutritional profile than the current raw materials being used, like cornflour or potato starch,” he said, pointing out that healthier products could be made, for example, using grains such as buckwheat or amaranth.


He added that manufacturers should also add more complete and clearer labels to products to highlight their nutritional content, including levels of vitamins and minerals.


Benjamin Lebwohl, from the coeliac disease centre at Columbia University, who was not involved in the research, said that the study backs up previous evidence that gluten-free foods are nutritionally suboptimal. But while a gluten-free diet is essential for coeliacs, it is not intrinsically healthy or unhealthy, he added. “It depends on the choices you make as part of the gluten-free diet,” he said.


Sarah Sleet, chief executive of Coeliac UK, said the latest findings tie in with the charity’s own research, adding that further development of lower-fat, gluten-free products would be welcomed.


David Sanders, professor of gastroenterology at the University of Sheffield, noted that other studies have found gluten-free and conventional foods to have similar nutritional value. “The jury is out,” he said.


But Sanders cautioned that there is no evidence a gluten-free diet has benefits for those without gluten sensitivity or coeliac disease. “Once you go into the territory of dietary restrictions without medical symptoms then you are running the gauntlet of missing out on various vitamins or minerals without realising it,” he said.



Gluten-free diet carries increased obesity risk, warn experts

22 Kasım 2016 Salı

One in 100 healthy people carries heart-condition gene

One in every 100 healthy people carry a faulty gene that could trigger a dangerous heart condition, scientists have found. Researchers at Imperial College London and the MRC Clinical Sciences Centre say 1% of the population are at risk from heart failure when the organ is placed under abnormal stress – such as through pregnancy or alcoholism – even if they appear otherwise healthy.


The study, published in the journal Nature Genetics on Monday, involved looking at rats with a faulty version of a gene called titin. They found that although the rats appeared healthy, placing abnormal stress on the heart triggered a rare heart muscle condition called dilated cardiomyopathy (DCM), which causes heart failure. DCM is a disease that stretches and thins the heart muscle so it becomes unable to pump blood around the body efficiently. It affects one in 250 people in the UK and is the most common cause of heart transplants.


The researchers also looked at the genes of 1,400 healthy adults and created detailed 3D computer models using scans of their hearts at the MRC centre in London.


As expected, 15 people (about 1%) had the titin gene mutation. From looking at the 3D heart models, the scientists found that healthy people with the titin mutations had a slightly enlarged heart, compared with those who did not have the mutations. Researchers said this supported the findings in mice that suggested titin mutations, even in the absence of DCM, were having an impact on the heart, but that this started in a very subtle way.


Research is under way to find out which genetic factors or environmental triggers may put people with titin mutations at risk of heart failure.


Prof Stuart Cook, who led the study, said: “We now know that the heart of a healthy individual with the titin gene mutation lives in a compensated state and that the heart’s main pumping chamber is slightly bigger. Our next step is to find out which are the specific genetic factors or environmental triggers, such as alcohol or viral infection, [that] may put certain people with titin mutations at risk of heart failure.”


Prof Sir Nilesh Samani, medical director at the British Heart Foundation, which partly funded the study, said: “Most people with titin mutations live a long and healthy life but some will develop DCM.


“This excellent research shows us that there is much more to this condition than we originally thought. We can now use this knowledge to identify preventable or avoidable factors that trigger DCM in those who carry titin mutations and also develop new treatments for DCM [that] target the genetic basis of the disease.”



One in 100 healthy people carries heart-condition gene