Valley etiketine sahip kayıtlar gösteriliyor. Tüm kayıtları göster
Valley etiketine sahip kayıtlar gösteriliyor. Tüm kayıtları göster

24 Haziran 2014 Salı

The Valley of Astonishment evaluation a sensory meditation on the human brain

Kathryn Hunter and Jared McNeill in The Valley of Astonishment.

Effortless and unforced … Kathryn Hunter and Jared McNeill in The Valley of Astonishment. Photograph: Tristram Kenton for the Guardian




Nervous theatre-makers strain each and every nerve to get our focus. But the striking factor about this 75-minute piece, written and directed by Peter Brook and Marie-Hélène Estienne, is its maturity, calm and aesthetic grace. It is as if its creators assume that we’re fascinated by the topic, the operating of the human brain, so they never need to have to shout and scream. The show grew out of an earlier piece, Je Suis un Phénomène, which dealt with memory. In this case, the emphasis is mostly on synaesthesia, in which a single sense is stimulated by one more. We comply with the fortunes of a fictive female, Sammy Costas, whose ability to see phrases as photos provides her a phenomenal memory. Fired as a journalist and investigated by cognitive scientists, she turns into a music-hall performer who is in the long run traumatised by her uncommon present. Her story is interwoven with that of a 28-12 months-old guy who relates music to colours and with a review of a senior citizen whose impaired proprioception, or inability to sense his physique, indicates he has to use his brain to overcome muscular paralysis.


What, some will request, does this have to do with theatre? In the hands of Brook and Estienne, almost everything. They engross us in the human predicament of Sammy, whose mnemomic electrical power is each blessing and curse. We see precisely how she is able to memorise the opening of Dante’s Inferno while understanding how, when it comes to numbers, she’s tormented by her inability to overlook. But the demonstrate, in its range of tone, also reminds a single of Brook’s well-known categorisation, in The Empty Area, of “holy” and “rough” theatre. Here holy theatre is exemplified by passages from The Conference of the Birds that give the display its title. But when Marcello Magni, as a a single-handed magician, persuades audience members to participate in card tricks, we are into the planet of popular theatre.


The present is staged with minimalist beauty nothing at all appears on the pristine white platform that is not employed. The acting is similarly unforced: Kathryn Hunter, as Sammy, suggests an ordinary lady bewildered by her extraordinary energy Magni effortlessly switches from white-coated scientist to genial card trickster and Jared McNeill conveys the relief of a man whose comprehending of synaesthesia enhances his adore of jazz. The two musicians, Raphael Chambouvet and Toshi Tsuchitori, are also integral to underscoring the show’s quiet astonishment at the miracles of the human brain.


• Until finally twelve July. Box workplace: 020-7922 2922. Venue: Youthful Vic, London.




The Valley of Astonishment evaluation a sensory meditation on the human brain

25 Şubat 2014 Salı

The Dalai Lama"s Phrases For Silicon Valley Leaders

On the final day of his three-day swing by the Bay Location, the Dalai Lama sported his Santa Clara University visor Monday morning as he told a Silicon Valley audience that businesses need to teach compassion.


In a area filled with the world’s largest tech giants, the Dalai Lama emphasized the value of compassion in the workplace for diminished anxiousness, pressure and undesirable overall health.


“Modern health-related care is run like a organization, but even business wants a sense of ethics,” he stated. “Since we have a physique and thoughts, we need that psychological peace and bodily comfort to which compassion offers rise. We require to educate folks to enhance their concern for others’ properly-being.”


The Dalai Lama was joined at the offered-out discussion known as, “Compassion, Company and Ethics: A Dialogue with the Dalai Lama,” by Lloyd Dean, CEO of Dignity Wellness, the fifth largest hospital program in the nation and biggest non-revenue hospital provider in California.


Regardless of up and coming companies delivering optimistic rewards such as childcare, gyms and environmentally friendly buildings that inspire folks to walk, Dean mentioned statistics display personnel of those businesses have substantial rates of depression, anxiety and traumatic experiences that are obviously induced by the work setting.


“Whether you are offering me a cost-free dinner or cost-free lunch turns into irrelevant because you are helping me improve anxiety and not have a good quality of existence,” mentioned Dean.


“I feel where the harm takes place and in which I think your query is rightly focused, is when the benefits are really–it’s the intention that goes with it–that folks by no means leave function and function sixteen hrs a day.”


In the second element of the event, the Dalai Lama took element in the discussion of “Incorporating Ethics and Compassion into Enterprise Life” with Charles Geschke, Adobe co-founder, Jane Shaw, retired chairman of Intel’s board of directors and Monica Worline, a study fellow from CompassionLab at the University of Michigan.


Shaw stated an illustration of compassion at work was when Intel grew to become conscious that certain resources have been becoming manufactured accessible as a end result of the intensely violent conflict in the Dominican Republic of Congo, steps had been taken to make certain that the organization did not use this kind of “conflict minerals” for its products.


The event was cosponsored by two of the country’s leading institutes for the study of ethics and compassion—Santa Clara University’s Markkula Center for Utilized Ethics and Stanford University’s Center for Compassion and Altruism Study and Education. The talk can be viewed here.


The Dalai Lama’s two-week speaking tour in the U.S. continues these days in Los Angeles at the Forum, according to his schedule.


However the 78-12 months-outdated Tibetan’s talks in the Bay Location had been fully sold out, his U.S. visit did not come with out animosity. Protestors who believe the Dalai Lama discriminated Buddhists by banning the worship of a 500-yr-outdated deity named Dorje Shugden are following his tour by means of southern California. The Chinese government also reportedly accused the U.S. of meddling after Obama met with the Dalai Lama.



The Dalai Lama"s Phrases For Silicon Valley Leaders

31 Ocak 2014 Cuma

Healthcare Entrepreneurs Learn Essential Lesson From The Valley: Your Answer Is Not My Problem

The place do excellent products come from?  Are they driven by a breathtaking engineering advance, that suddenly permits you to remedy a variety of troubles in radical information methods, or do them come from listening closely to customers, figuring out precisely what they really want, and developing some thing exquisitely fit for objective?


For several – particularly in the academy – building radically new science or potent new technologies looks like the most essential path to health-related progress: figuring out what triggers cancer, or diabetes, or Alzheimer’s illness would most likely reveal crucial therapeutic options in every of these critical locations.


But reaching a scientific breakthrough or establishing a cool engineering doesn’t assure a valuable application will inevitably emerge.


In many circumstances, disappointed innovators and entrepreneurs belatedly learn that, as VC Dave McClure typically puts it (usually much more colorfully), “your solution is not my dilemma.”


Many wonderful concepts never go anywhere numerous large-potential startups fail because their resolution, although stylish, can not be matched to a problem somebody desires to fix.


I saw this vividly nearly a decade in the past, when I was asked to weigh in on a startup that created an remarkable drug delivery engineering, but could by no means figure out what medicine to in fact put in the device – they couldn’t figure out the killer app, so to speak.  It was a resolution in search of a difficulty, and it by no means located traction.


Much more just lately, I noticed this in the context of a new solution a big information startup was striving to promote even though the technological innovation was really mindblowing, the advantages the business was touting — such as a turnaround time of months vs days — didn’t resonate, due to the fact incumbent vendors supplied equivalent companies.   The new solution almost certainly had important differentiating functions, just not the ones the organization was selling.


Digital health entrepreneurs seem to be specifically vulnerable to this, frequently building classy technological offerings without having contemplating whether or not it solves a dilemma for which a client is ready to spend.  Innovators banking on the imminent arrival of value-primarily based care may possibly be particularly likely to find themselves in an awkward and uncomfortable scenario.


The require to much better recognize clients is also an important theme of Phil Rosenzweig’s just published Left Brain Proper Things  (my current WSJ review right here).   Rosenzweig explores why CEOs generally disregard decision analysis, and concludes that the highly managed conditions of experimental social science translate poorly to the true-globe, higher-stakes choices senior executives confront.   The solutions in this spot do not successfully talk to executives’ issues, major the writer to suggest researchers need to develop a greater comprehending of these messy complexities if they aspire to supply far more appropriate options.


An critical, perhaps inadequately appreciated example of the need for customer discovery comes from the pharmaceutical business, exactly where long and extremely uncertain merchandise growth cycles, mixed with a quickly changing external surroundings, has resulted in an abundance of clinical stage compounds that have grow to be efficiently stranded as the marketplace has altered.  Medication that have been initially created below 1 set of situations – with the goal of creating an enhanced hypertension drug, say, or a better diabetes drug – now seem to be much less exciting, leading the organizations that produced them to appear earnestly for new potential indications they are options in search of issues, and they are exceptionally frequent across the industry.


In response to the recurrent “your resolution is not my problem” challenge, many silicon valley specialists have been pushing an method that places far much more emphasis on customer want.


Ideo’s Kelley brothers, for instance, in their fantastic Innovative Self-assurance, continually emphasize human factors, the significance of “getting at people’s motivations and core beliefs,” and “deeply understanding human needs” – normally by going out and speaking to men and women and figuring out what these needs are.


Similarly, entrepreneurship guru Steve Blank has urged innovators to emphasis on client development, a priority he sophisticated in a latest program close to life science entrepreneurship he organized at UCSF and meticulously documented on his site.


Intriguingly, during his course, Blank asserted that customer growth represents a crucial missing hyperlink in translational study, as a lot of would-be innovators have a remarkably bad knowing of the consumers they are making an attempt to serve (articulated nicely in this Burrill Report podcast as well).   Throughout Blank’s program, group right after group of entrepreneurs had been startled by what they identified when they started to speak to customers, interactions that led numerous to revise their approaches dramatically.


Significantly, neither the Kelleys nor Blank are advocating customer advancement as a stand-alone technique, and each explicitly emphasize the worth of innovative engineering.  Their level is basically that if you want to be certain your technology is going to be beneficial to clients, you better place some hard work into thinking about who your clients actually are, and what they really want.


Great suggestions, of course – but what do you do when the moment has passed, when you’ve presently developed a promising solution, a powerful engineering, and risk-free new medication, some thing you feel has acquired to be helpful to somebody, someplace, but have no concept where the worth lies?  How do you connect merchandise with need?


Regrettably, that is a issue in search of a answer.



Healthcare Entrepreneurs Learn Essential Lesson From The Valley: Your Answer Is Not My Problem

18 Ocak 2014 Cumartesi

To End California Drought, Fill Much more Hollywood And Silicon Valley Swimming Pools


For each action, there is an equal and opposite government system.  —unknown



Jerry Brown and Linda Ronstadt on the cover of...

Jerry Brown and Linda Ronstadt, 1979 (Photograph credit score: Jack Snell)





1 the heels of a West Virginia water contamination crisis, California hosts a grave water emergency.


Gov. Jerry Brown delivered the  news, calling the drought emergency there an “unprecedented, severe scenario.”


The western climate is largely irrigated desert, yet, gallons of H2O value less than a penny, and scarce water fills opulent swimming pools and quenches California desert lawns.


The very good news is water is not acquiring a lot more scarce general it is an earthly consistent.  The Massive Thirst by Charles Fishman referred to:



Olympian springs of fresh water — every single day, the sun, the sea and evaporation mix to make 45,000 gallons of rainwater for every guy, lady and kid on Earth….Even in the United States, the place we use water with profligacy, the oceans are making a lot more fresh water for each of us in a month than we’ll use in a decade.



But allocation and pricing of that bounty do matter. On boring days when the swimming pool seems to be inviting, water’s total utility is large and “marginal utility” minimal compared to diamonds, as the outdated lesson in economics illustrates.


But, wow, does that marginal utility of an extra gallon skyrocket in the course of a shortage. Water’s cost trajectory rapidly tops that of chainsaw following a hurricane.


Western and California landscapes and waterscapes are organic wonders but so too is the outstanding manmade infrastructure western environments are some of the most artificial on earth (sorry, resident greens).


Offered that, no shock will ensue on hearing that all the western states frequently beat a path to Washington for federal drought relief funding and planning.


The most recent was the late 2013 reauthorization of the Reclamation States Emergency Drought Relief Act, on which I testified in the Residence of Representatives.


This kind of federal efforts won’t break the fiscal financial institution.


But they gravely distract from the infrastructure and regulatory liberalization actually necessary for adaptable, plentiful water in arid areas.


Plus, politics encourages resource management principles at odds with an adaptable and lightly regulated water sector, and critical infrastructure wellness typically.


Pet agendas like desalination do boast remarkable doing work applications, but they are frequently vitality-intensive, by-product-laden approaches to make costly drinkable water. They’re not sustainable, however.


Politics has difficulty with tradeoffs: Why brackish groundwater desalination alternatively of seawater desalination, or smaller scale solar nonetheless-kind projects, or why not a great number of different water investments and approaches?



To End California Drought, Fill Much more Hollywood And Silicon Valley Swimming Pools

10 Ocak 2014 Cuma

Can An Uber Investor Deliver Silicon Valley Disruption To Healthcare?

Numerous tweets right now from Benchmark Capital spouse Bill Gurley suggests that the legendary VC company – popular for their backing of eBay, Uber, OpenTable, and Yelp, amongst others – could be preparing to get critical about healthcare, and aggressively crowdsource their search for new options.


“Spending time learning where the Web intersects with healthcare. If you have concepts and want to chat, get in touch with me: overall health@benchmark.com,” he initially tweeted, incorporating, “100% convinced US healthcare industry is genuinely messed up &amp that implies possibility, 17% of GDP.”


Possibly most interestingly, Gurley mentioned that “approach must be orthogonal/disruptive. Not interested in ideas that spouse closely with current players.”  He asserts,“i dont want a swift exit, but I really do not want to fret about trials and regulation as well considerably both.“


This positioning would seem to align Gurley with other engineering VCs like Vinod Khosla, who believe the greatest opportunities lie in operating outdoors the present program, which they tend to view as irredeemably dysfunctional.


Others firms, although possibly sharing a similar view of the status quo (“calcified hairball program of care”), nevertheless appear to strive to recognize solutions that address discomfort-points of existing gamers, and more usually, try to operate inside of the framework of the current system.  I’d spot Venrock, Aberdare, and Sequoia in this class.  Notably, Venrock’s efforts right here are led by physician Bob Kocher, Aberdare has a legacy in existence science and just lately pivoted to healthcare providers and digital wellness (capstoned by the hiring of doctor Mo Kaushal), and Sequoia’s efforts appear to be led by former healthcare CEO, Todd Cozzens.


(Conspicuously absent from this list are companies like Social+Capital, my 2013 digital well being investor of the year although I might be tempted to place founder Chamath Palihapitiya squarely in the Gurley/Khosla camp, at least some of his portfolio companies, this kind of as Geoff Clapp’s Better, seem to be centered, at least initially, on functioning inside of the existing technique.)


The basic question isn’t so a lot no matter whether healthcare requirements disruption (it does), but rather, whether this adjust is far more probably to be achieved by brash brilliant upstarts, working from with no, or by savvy, visionary insiders, who know exactly where to search for seams.


A latest, unsettling HBR publish by Jason Hwang (co-author of The Innovator’s Prescription) and Ateev Mehrotra, describes what they see as the failure of retail clinics to transform healthcare.  “Understanding their disappointing overall performance is especially critical,” Hwang and Mehrotra  write,



“given that retail clinics are viewed as the prototypical illustration of how disruptive innovation can alter the health care system for the better. The thought of disruptive innovation, a idea pioneered by the Harvard Enterprise School’s Clayton Christensen and written about previously in HBR and in a book that one particular of us co-authored, is that industries are a lot more generally transformed by new entrants, rather than entrenched gamers. Disruptive firms get their start off by supplying affordability, ease, and simplicity to previously neglected market place segments that are too little and reduced margin for incumbents to pursue or aggressively defend.


Retail clinics match this description to a tee “



However, Hwang and Mehrotra argue, retail clinics have been derailed by “perversities in rules and reimbursement.”  (An assertion with which Christensen, as properly as HMS Dean Jeffrey Flier and researcher Vineeta Vijayaraghavan, would seem to agree.)


But, if any person has purpose to believe in the potential of a promising thought to overcome “perversities in regulation,” it just may well be Bill Gurley, a fellow who invested in an upstart car support that that has had to battle its way into a historically regulated and impenetrable market place, and  aside from displeasing Jessica Seinfeld,  seems to have been remarkably profitable.


The abiding hope is that whether or not led from the inside or the outside, the irresistible force of inspired entrepreneurship will find some way to dislodge the immovable object of contemporary healthcare.



Can An Uber Investor Deliver Silicon Valley Disruption To Healthcare?