More than a decade ago the Women’s Overall health Research made surprising and essential outcomes when it showed that broad use of hormone substitute treatment did not minimize cardiovascular threat in publish-menopausal females. But the study also led to speculation that hormone therapy might be beneficial when delivered closer to the time of menopause. Now a review published in Annals of Internal Medicine demonstrates that menopausal hormone therapy (MHT) might have some favorable results on some cardiovascular danger elements but it does not lessen the progression of atherosclerosis.
In the review, called KEEPS (Kronos Early Estrogen Prevention Research), 727 menopausal women were randomized to placebo or one particular of two types of low dose hormone treatment (oral conjugated equine estrogens or transdermal 17β- estradiol). Following four years there was no distinction between the groups in the primary endpoint of the research, which was the progression of atherosclerosis as measured by carotid artery intima–media thickness (CIMT). There was also no big difference in the coronary artery calcium scores. Ladies in the equine estrogen group had enhancements in their lipid profiles (decrease in LDL and increase in HDL) while women in the transdermal group had improved insulin sensitivity. There was no big difference in the incidence of significant adverse occasions.
The investigators supplied several explanations for the findings, like a research population at reduced danger for athersosclerosis, a reasonably quick examine duration, and the use of minimal dose but not large dose estrogen. “To the extent that these imaging strategies predict CVD events, our findings recommend that MHT neither is a chance nor is protective in the population studied,” they wrote. The study was not powered to appear at clinical events.
Andrew Kaunitz, a expert in women’s wellness and menopause at the University of Florida, explained that although it even now remains unclear what the prolonged term effects of hormone treatment will be on cardiovascular occasions, the study “does not assistance using hormone treatment to avert CVD events.”
Hormone Therapy At Menopause Fails To Halt Heart Illness Progression
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