14 Nisan 2017 Cuma
27 Mart 2017 Pazartesi
Stem cells help some men with erectile dysfunction after prostate surgery
Men unable to have an erection after prostate surgery enjoyed normal intercourse thanks to stem cell therapy, scientists are to report on Saturday at a medical conference in London.
In first-phase clinical trials, eight out of 15 continent men suffering from erectile dysfunction had sex six months after the one-time treatment, without recourse to drugs or penile implants.
The positive result showed no signs of flagging during a subsequent year-long monitoring period. “As far as we know, this is the first time that a human study with a 12-month follow up shows that the treatment is lasting and safe,” said Lars Lund, a professor at Odense University hospital in Denmark, who took part in the trials.
“That is much better than taking a pill every time you want to have intercourse,” he said.
The results were promising enough to convince Danish health authorities to authorise so-called phase III “double-blind” randomised trials in which one group of men is given stem cell therapy and another placebos.
Only men recovering from prostate cancer and able to control their bladders will be enrolled in the new experiments, Lund explained.
To perform the procedure, doctors remove fat cells from a patient’s abdomen via liposuction. The cells undergo a brief treatment and emerge as all-purpose stem cells, meaning they can mutate into almost any specialised cell in the body.
“We do not cultivate the cells or change them in any way,” said Lund’s colleague Martha Haahr, head researcher and lead author of a study detailing preliminary results, published last year in EBioMedicine.
The stem cells are then injected with a syringe into the penis, where they spontaneously begin to change in to nerve and muscle cells, as well as the endothelial cells that line blood vessels. Men are under general anaesthesia while all of this happens, and are discharged from hospital the same day.
Prostate surgery is responsible for about 13% of erectile dysfunction cases. Up to 80% of men experience difficulty having sex immediately after an operation, previous research has shown.
Diabetes accounts for 40% of erectile dysfunction cases, and vascular disease another 30%. Men with diabetes would be the next target group for clinical trials, Lund said.
The results reported at the European Association of Urology conference could be an effective “therapeutic option for patients suffering erectile dysfunction from other causes,” Haahr said.
It is estimated that nearly half of men between the ages of 40 and 70 experience erectile dysfunction to some degree.
The global market for drugs treating the disorder is expected to top $ 3.4 billion by 2019.
Failure to perform sexually can also, in some men, result from relationship problems, performance anxiety or repressed homosexuality, Haahr said.
Stem cells help some men with erectile dysfunction after prostate surgery
22 Mart 2017 Çarşamba
Cryogenic preservation: from single cells to whole organs – Science Weekly podcast
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Last year, around 3,500 organs were transplanted into patients in the UK alone. That said, a large number of organs were also discarded because the moment a donor dies, doctors have only eight or so hours to find a patient on the organ register who is a match and can be almost immediately ready for surgery. One recent estimate suggested that as many as 60% of the hearts and lungs donated for transplantation are discarded each year. But a new technology could be about to change this: whole-organ cryopreservation.
This week, Hannah Devlin looks at the past, present, and future of these technologies with University College London’s Professor Barry Fuller. We also hear from Newcastle University bioethicist Dr Simon Woods about some of the ethical issues that arise with any biotechnology, including cryopreservation.
Cryogenic preservation: from single cells to whole organs – Science Weekly podcast
15 Şubat 2017 Çarşamba
3 Şubat 2017 Cuma
27 Ocak 2017 Cuma
Substances in Cinnamon Affect Breast Cancer Cells
The Egyptians, the Chinese and ancient Europeans used to use the brown bark of the cinnamon tree for its anti-bacterial, anti-fungal, anti-inflammatory and even food preservation properties. Recent studies have shown how cinnamon can have a direct effect on many kinds of cancer, including breast cancer.
What is in cinnamon that makes it such a cancer healer?
Cinnamon contains an extraordinary amount of cancer-healing substances within it; cinnamaldehyde is probably the most studied substance within this warming herb. It has demonstrated its antiproliferative (anti-cancer) properties in quite a few studies, especially when it comes to lung and colon cancer. A 2015 study conducted by the University of Arizona found that cinnamaldehyde in Cassia cinnamon suppressed colorectal cancer metastasis through inhibiting inflammatory responses which help cancer cells to grow. Other studies have found cinnamaldehyde to have an effect on liver cancer cells. Studies have also shown that cinnamaldehyde prohibits the mechanisms of VEGF, or vascular endothelial growth factor, a major contributor to cancer cell growth.
In addition, cinnamon contains the phenylpropene, eugenol, which has proven its healing abilities on breast cancer cells. According to a 2013 study conducted by the King Faisal Specialist Hospital and Research Center in Saudi Arabia, the eugenol in cinnamon inhibited the substance Survivin in various kinds of breast cancer cell lines. Survivin is produced by cancer cells to help them avoid normally-occurring cellular death. Essential oils of clary sage, holy basil and clove also contain high levels of eugenol.
Finally, cinnamon contains the phytoestrogen coumarin, which may also have a positive effect on breast cancer growth and metastasis. Contrary to popular belief, naturally-occurring phytoestrogens do not need to be avoided when one is healing or wanting to prevent breast cancer. In fact, the phytoestrogens found in flax and pumpkin seeds, as well as in cinnamon, provide mild forms of estrogen which can help reduce estrogen-positive breast cancer tumors or prevent them from ever developing in the first place.
Phytoestrogens attach to cellular receptors within the mammary glands, replacing more “aggressive” xenoestrogens (or chemically-created estrogen “mimics”) with milder, naturally-sourced mimics. Xenoestrogens are the main culprit in the vast majority of estrogen-positive breast cancers diagnosed each year.
Going along with cinnamaldehyde and eugenol’s cancer-culling effect are the detoxification properties of fiber, calcium and manganese that cinnamon provides. Fiber and key essential minerals can add to cancer prevention, especially from colon cancer.
Other Healing Properties of Cinnamon
The properties found in cinnamon have other benefits too. As a super-antioxidant, cinnamaldehyde has the ability to chelate metals from the body. A comprehensive review conducted by the MD Anderson Cancer Center in Texas also found that the nutraceuticals in cinnamon were neuroprotectant and should be studied further for its benefits for Parkinson’s and Alzheimer’s patients
“Research over the last 10 years has indicated that nutraceuticals derived from such spices as turmeric, red pepper, black pepper, licorice, clove, ginger, garlic, coriander, and cinnamon target inflammatory pathways, thereby may prevent neurodegenerative diseases,” the report stated.
Finally, cinnamon is a known blood-glucose stabilizer, as demonstrated by several studies. Cinnamon supplementation is often recommended by natural health practitioners for help with Type 2 diabetes.
Cinnamon has been a healing herb in Asia and elsewhere for thousands of years and new scientific evidence is proving its cancer-healing and prevention power along several fronts. Now every time you sprinkle some on this delicious spice on a warm beverage or food, you will know that you are heading in the right direction and towards a healthy, vibrant, cancer-free life!
Dr. Veronique Desaulniers, better known as Dr. V, is the founder of the 7 Essentials System ™, a step-by-step guide that teaches you exactly how to prevent and heal Breast Cancer naturally. To get your FREE 7-Day Mini e-Course and to receive her weekly action steps and inspiring articles on the power of Natural Medicine, visit her at BreastCancerConqueror.com
Substances in Cinnamon Affect Breast Cancer Cells
13 Ocak 2017 Cuma
19 Aralık 2016 Pazartesi
16 Kasım 2016 Çarşamba
Ban use of police cells for people in mental health crisis, MPs told
People suffering a mental health crisis should never be held in police cells as they find it terrifying and become even more unwell, ministers will be told.
Peers will move an amendment to the policing and crime bill on Wednesday to ensure that adults who are feeling suicidal, are psychotic or are self-harming are never taken to police stations for assessment. It already plans to do that for under-18s.
The number of people to whom that happens has fallen sharply in recent years and the number taken instead to hospitals has risen as a result, after widespread concern about the practice.
“When you’re in a mental health crisis you may become frustrated, frightened and extremely distressed. Your behaviour could be perceived as aggressive and threatening to others, but you desperately need support and compassion,” said Paul Harmer, the chief executive of the mental health charity Mind, which is leading the calls to end the practice.
“Being held in a police cell and [in effect] treated like a criminal only makes things worse. Now is the moment to ban this damaging practice once and for all.”
Figures show there were 2,100 instances of adults being detained under section 136 of the Mental Health Act in police cells in England and Wales during 2015-16, and it also happened with 43 children and young people aged under 18.
West Yorkshire police detained people 269 times in a police cell under section 136 during 2015-16, while Avon and Somerset did it 242 times, and South Wales 192. Officers usually take someone in crisis to a cell only when there is no “place of safety” available in a local NHS hospital.
Yet, the 2,100 figure was 53% fewer than the 4,537 to whom that happened the year before. Numbers fell dramatically during Theresa May’s time as home secretary from 2010. For example, in 2011-12 a total of 9,000 people were taken to police cells after being detained.
Similarly, the number of under-18s taken to a police cell had fallen from 256 in 2013-14 to 43 last year.
Joan Walmsley, a Liberal Democrat peer, will use the Lords debate on Wednesday to try to push through the change.
Insp Wayne Goodwin, Kent constabulary’s mental health liaison officer, said: “Kent police believe the use of police cells for those detained under the Mental Health Act should be a never event. Cells are not appropriate places for anyone detained under the act and we know that their use can add to the trauma of the crisis and potentially delay that person’s recovery.”
The Home Office said adults should only be taken to police cells in “exceptional circumstances” but did not comment on the call for a ban.
A spokeswoman said: “We are committed to ensuring those in mental health crisis get compassionate care and that no one is taken to a cell when they have committed no crime and solely because there is no alternative safe place for them. Significant progress has been made by the police and health partners in halving the use of police cells for those in mental health crisis over the last year. But there is still more work to be done.
“Changes to legislation through the Policing and Crime Bill will ban the use of police cells for under 18s in mental health crisis, and ensure they can only be used as a place of safety for adults in genuinely exceptional circumstances.”
Ban use of police cells for people in mental health crisis, MPs told
2 Kasım 2016 Çarşamba
28 Ekim 2016 Cuma
Study: Frankincense Essential Oil Superior to Chemotherapy in Destroying Cancer Cells
What is frankincense?
Frankincense is a fragrant plant resin that comes from the Boswelllia sacra tree found across Africa and the Arabian peninsula. It’s been used for centuries as a folk medicine, largely because of its anti-inflammatory properties. The oil of frankincense has been used for thousands of years to treat and prevent disease-causing inflammation, boost immunity, and prevent dangerous infections.
Cancer Cells that Don’t Respond to Chemotherapy are Destroy by Frankincense Oil
In the latest research, scientists have demonstrated the ability of frankincense to combat cancer cells in late-stage cancer. The compound known as AKBA (acetyl-11-keto-beta-boswellic acid) is credited with many of the known benefits of the resin, including its positive effects on cancer elimination, including breast, colon, and prostate cancers. And the evidence suggests that frankincense isn’t just a supplemental treatment to go along with chemotherapy and radiation; in some cases it may actually be preferential as a replacement.
After a year of studying the AKBA compound with ovarian cancer cell lines in vitro, we have been able to show it is effective at killing the cancer cells. Frankincense is taken by many people with no known side effects. This finding has enormous potential to be taken to a clinical trial in the future and developed into an additional treatment for ovarian cancer.
The reason for this is that frankincense shows demonstrable effectiveness in a few areas where chemotherapy isn’t all that effective, particularly with regards to ovarian cancer.
How to use Frankincense Essential Oil?
Frankincense essential oil can be diluted in a carrier oil such as jojoba oil or coconut oil, or add it to your favorite all-natural lotions or creams for topical application.
Other Benefits & Uses of Frankincense Essential Oil
-Stress Relieving Bath-Soak
-Natural Household Cleaner
-Anti-Aging & Wrinkle Fighter
-Relieve the symptoms of gout
-Stress and anxiety management
-Relieves Symptoms of Indigestion
-Natural Cold or Flu Medicine
-Reduce Swelling from Insect Bites
-Helps Relieve Inflammation and Pain
-Wound Healing and Infection Prevention
-Remove moles, skin tags, and warts
Additional Sources:
https://thetruthaboutcancer.com/frankincense-and-cancer/
http://complete-health-and-happiness.com/frankincense-essential-oil-could-be-superior-to-chemotherapy-in-destroying-cancer-cells/?t=HHL
https://draxe.com/frankincense-oil-cancer/
More Articles:
Study: Frankincense Essential Oil Superior to Chemotherapy in Destroying Cancer Cells
23 Eylül 2016 Cuma
Shocking Study: E-Cigarette Vapor Kills 85 % of the Cells in Your Mouth
Smoking e-cigarettes may not be much safer than tobacco when it comes to oral health, a new study suggests. People claim that EC can reduce the harm which regular cigarettes are causing. But this theory has many holes in it. According to the Centers for Disease Control and Prevention (CDC), between 2011-2012, e-cigarette use more than doubled among 15 and 19 age students in the United States, and in 2014, more than a fifth of adults who currently smoke reported also using e-cigarettes.
What Are E-Cigarettes?
E-cigarettes are battery-operated electronic devices that provide a way to get nicotine. Nicotine is an addictive drug that is naturally found in tobacco. E-cigarettes also allow nicotine to be inhaled, but they work by heating a liquid cartridge containing nicotine, flavors, and other chemicals into a vapor.
New Study Conducted by Dr. Shen Hu
A number of studies have shown that electronic cigarettes are not as harmful as the conventional cigarettes. New researchers found e-cigarettes contain toxic substances and nano-particles that could kill the top layer of skin cells in the oral cavity behind teeth and gums.
The researchers – led by Dr. Shen Hu, an associate professor of oral biology at the University of California-Los Angeles (UCLA) – came to their conclusion by analyzing the effects of e-cigarette vapor on cell cultures in laboratory tests.
How it Effects Our Oral Health
Inhaling heated chemicals, including the e-liquid ingredients nicotine, couldn’t possibly be good for you.
Vapours contain toxic substances and particles which damage skin cells.
Exposure reduced body’s natural defences of the antioxidant glutathione.
Scientists say it could lead to increased risk of oral disease like cancer.
Conclusion:
“On assessing the effects of e-cigarette vapor on oral cavity cell cultures, the researchers found that the vapor reduced levels of glutathione within the cells, which is an important antioxidant that protects them from damage. As a result, the e-cigarette vapor destroyed around 85 percent of the cells.”
The substance directly kills airway cells and weakens the immune system, researchers found.
Sources:
1) http://www.medicalnewstoday.com/articles/311313.php
2) http://healthyhousetips.com/reasons-stop-using-e-cigarettes/
3) http://www.dailymail.co.uk/health/article-3663839/E-cigarettes-toxic-mouth-Vaping-kills-cells-oral-cavity-raising-risk-disease.html
4) http://www.healthy-holistic-living.com/ecigarette-vapor-destroys-mouth.html?t=DA
Look Also:
Shocking Study: E-Cigarette Vapor Kills 85 % of the Cells in Your Mouth
9 Ağustos 2016 Salı
26 Aralık 2015 Cumartesi
Parsley destroys 86 percent of lung cancer cells and is successful in killing breast, ovarian, pancreatic, prostate and colon cancers!
In 1987, lung cancer replaced breast cancer as the major lead to of cancer deaths in girls. More and far more study continues to point out the correlation amongst diet program and cancer. (one)
In February 2015, the American Cancer Society suggested that cancer survivors adhere to a “prudent diet” and exclusively suggested a plant-primarily based diet plan that is high in fruits, greens, unrefined grains and is minimal in red meat, processed meats, refined grains and sugars.(2)
American Cancer Society recommends that cancer survivors eat a plant-primarily based diet program!
Far more and much more research has been carried out to assess the link among our foods provide and cancer remedy. A 2013 research identified that parsley killed up to 86 percent of lung cancer cells. Parsley consists of a flavonoid known as apigenin. Other plant sources of this flavonoid consist of celery, onions, oranges, chamomile tea, oregano, thyme, coriander, artichokes, and red wine. (1)
Dried parsley consists of four.five % pure apigenin coming in the highest in apigenin content material by excess weight. Other research have located act apigenin can destroy breast cancer, ovarian cancer, pancreatic cancer, prostate cancer and colon cancer cells. (1)
Apigenin discovered in parsley killed 86 percent of lung cancer!
A 2005 research located that apigenin inhibits the cell proliferation of lung cancer cell lines and advisable a blend of apigenin and anti-tumor medicines. (one)
A review from Ohio State University’s Thorough Cancer Center identified that apigenin inhibited breast cancer cells “immortality.” Researchers identified that this takes place due to shifting a stage involved in gene regulation. This reprograms cancer cells by turning them into standard mortal cells that die naturally. (1)
Apigenin found to inhibit breast cancer cells “immortality,” reprogramming them into mortal cells that die naturally!
An Italian study found that eating parsley frequently resulted in a 68 percent reduction in lung cancer chance.(1)
Parsley is a effective antioxidant that has been employed as a diuretic. Parsley has been effectively employed in treating and curing kidney stones, continual irritation, and prostate and uterus concerns. (1)
Traditionally parsley has been used to treat or break-up kidney stones. In truth, the German Commission E, a governmental advisory panel, has accredited parsley for the prevention and the treatment of kidney stones. (1)
Parsley is wealthy in vitamin K, vitamin C, B-complix, iron, magnesium, chlorophyll, and histidine. Eating a diet plan wealthy in parsley can not only aid battle cancer but can enhance antioxidant amounts in the brain and regulate blood stress. (one)
If you want to incorporate a lot more of these apigenin foods into your diet, consider adding parsley to a salad, soup, or primary dish. If you have a juicer, stick to this basic recipe beneath or if you do not have a juicer, just add parsley to your preferred green smoothie recipe!
Fresh Apple-Celery Juice with Ginger and Parsley
Ingredients:
- 2 celery ribs, cut into three-inch lengths
- 1 Granny Smith apple—halved, cored and cut into huge chunks
- One 2-inch piece of fresh ginger, peeled
- one/2 medium bunch of parsley with stems
- 1 1/two tablespoons fresh lemon juice
Directions:
- In an electrical juicer, juice the celery with the apple, ginger and parsley. Stir in the lemon juice. (three)
Sources incorporated:
(one) http://www.endoriot.com/2015/01/parsley-compound-kills-86-of-lung.html
(2) http://www.forksoverknives.com/science-says-about-diet plan-and-cancer/
(3) http://www.foodandwine.com/recipes/fresh-apple-celery-juice-with-ginger-and-parsley
Parsley destroys 86 percent of lung cancer cells and is successful in killing breast, ovarian, pancreatic, prostate and colon cancers!
21 Temmuz 2014 Pazartesi
HIV breakthrough reveals virus hidden in immune program cells
Danish researchers have used an anti-cancer medicine to to activate HIV hidden in the cells of patients taking anti-HIV medication, exposing the virus to the immune program and making it vulnerable to assault.
The final results uncovered on Tuesday have been hailed as a single of the key scientific breakthroughs to come from the Aids 2014 conference in Melbourne, as considerably of the language shifts away from obtaining a cure to focusing on breakthroughs in HIV treatment and prevention.
HIV hides in a state of hibernation in CD4 cells, an crucial element of the immune program. Nevertheless CD4 cells are unable to battle HIV themselves – that function lies with the immune system’s killer T-cells.
But simply because killer T-cells can’t detect the HIV hidden inside of CD4 cells, they are unable to attack and eradicate it from the entire body. Whilst HIV patients on antiretroviral drug remedy usually go on to have undetectable levels of HIV in their system, it is in no way eliminated.
There is usually a reservoir left hiding in cells, undetectable to existing screening tools and ready to consider hold of the immune system again must sufferers quit their antiretroviral therapy.
But a investigation team led by Ole Søgaard at Aarhus University’s department of infectious ailments in Denmark has utilised the anti-cancer drug romidepsin to activate the virus and deliver it out of hiding.
In principle, this implies that the killer T-cells need to be ready to detect the virus, since it leaves a trace on the outside of CD4 cells as it is activated and moves in the direction of the bloodstream, Søgaard mentioned.
“Despite really powerful antiretroviral remedy, there is still this reservoir left of HIV cells that are infected but not producing the virus,” he mentioned.
“Once you activate them, these particles will go to the surface and signal to the immune method that this cell is contaminated and wants to be cleared from the entire body. So this is a two-phase program where we bring the cells to the surface, and then rely on the immune method to kill them.”
In the pilot examine, researchers gave 6 individuals 3 doses of romidepsin above three weeks.
Just before each dose, no viral particles have been detectable in the patients.
“But after the dose was provided we simply measured the virus becoming launched into the plasma in 5 of these six individuals,” Søgaard mentioned.
“We also saw the virus go back to undetectable levels following 7 days, so it came up, then hid away yet again, returning back to a non-energetic state until the subsequent dose of cancer drug was provided.”
Nonetheless, the researchers identified the immune technique did not appear to assault the virus following detecting it. Researchers located no considerable reduction in the variety of infected cells each and every time the cancer drug brought the virus out of hiding.
“This suggests when you do this reactivation, you also need to also target and activate the immune technique and educate it to recognise these cells and assault,” Søgaard mentioned.
“That’s what we’re undertaking following in this examine. We will teach and prime the immune program to recognise HIV ahead of we give individuals the cancer drug, and we hope there will be a better possibility the immune program can clear these cells when the HIV is reactivated.”
Søgaard emphasised it was unknown how a lot of the HIV reservoir the immune method would be able to clear even if it could be taught to recognise the virus and attack it. Virus left in just a single cell may be ample to permit HIV to thrive once again.
“We’re nonetheless understanding about this disease and the place it hides, and it is a truly, genuinely difficult condition to cure since it hides in so many locations in the body, it hides genuinely properly and can hide for an indefinite time period of time,” he explained.
The trouble of an HIV cure grew to become particularly apparent with the now popular situation of the Mississippi infant, born to an HIV-good mom.
The youngster was placed on a powerful program of antiretroviral drugs inside thirty hours of birth. She continued the therapy for 18 months and when she stopped taking these drugs, she had no detectable virus in her system. It gave hope other infants taken care of early might be cured.
But 27 months later on, the virus was detected and she was placed on antiretroviral medication once again.
In a equivalent situation, two Boston patients acquired bone marrow transplants that appeared to rid them totally of HIV. They also relapsed, and are now back on antiretroviral remedy.
These instances have been referred to regularly throughout the AIDS 2014 conference, at times brandished as setbacks. But the cases reveal how far HIV therapy has come.
Attaining much more than two years with no antiretroviral therapy in an infant is unprecedented, especially because the Mississippi little one had no existing immunity to HIV. It has given researchers a new emphasis on exactly where to battle HIV, as they now know it requires just a small amount of dormant virus for HIV to become energetic once more.
The circumstances have shown that doing work out precisely in which dormant HIV virus resides in the body, and being in a position to measure it, will be essential to future research.
The development of HIV into lethal Aids was after regarded inevitable, and much less than thirty years following the epidemic started – not a extended period in medical science – individuals residing with HIV are able to lead prolonged and healthier lives.
But that all depends on entry to treatment, which has the extra advantage of safeguarding towards the transmission of HIV throughout unprotected sex by up to 96%.
The president of the International Aids Society, Françoise Barré-Sinoussi, won a Nobel prize for her function in discovering HIV and mentioned she would not be drawn into talk about how far away a remedy for HIV/Aids may possibly be.
“I bear in mind in 1984 a person mentioned we would have a vaccine inside of two years, and we are now 30 many years later,” she explained.
“We should move on from this. We will need to have to collaborate and combine distinct approaches to HIV – work on cures as effectively as therapies, prevention and vaccines – and strengthen the relationship among researchers to carry on to make progress in tackling HIV.”
HIV breakthrough reveals virus hidden in immune program cells
17 Haziran 2014 Salı
Leukaemia researchers discover genetic switch to fix cancer cells in mice
The most typical childhood leukaemia can be “cured” in mice with the flick of a genetic switch, Australian researchers have found.
Mice at Melbourne’s Walter and Eliza Institute produced a sort of leukaemia, B-ALL, right after possessing the “tumour suppressor” gene Pax5 deactivated. But when scientists switched the gene back on, they discovered the cancerous cells had been “coaxed” back to their normal state.
“The cells regain their identity,” a lead scientist on the research, Grace Liu, explained. “[The cancer] disappears from the blood, the bone marrow and all the regions exactly where the leukaemia typically develops.”
The findings have been published this week in the journal Genes & Improvement.
One particular-third of young children with leukaemia are located to lack healthful levels of Pax5.
When the gene is damaged or only partially current, developing white blood cells can become trapped in an immature state and flip cancerous.
The research is an instance of differentiation treatment, an method to cancer treatment that seeks to rehabilitate cells that have turn out to be malignant. Chemotherapy, by contrast, “just blasts the [cancerous] cells and causes them to die”, Liu stated.
Liu said it was “intriguing” that basically restoring Pax5 was sufficient to flip B-ALL cells to typical, as the gene is just 1 of several that are normally mutated in leukaemia.
But Dr Ross Dickins, yet another scientist on the review, said it would be tough to build medication to restore the Pax5 gene, or the “about 100” other genes known to suppress tumours.
“However, by comprehending the mechanisms by which Pax5 loss leads to leukaemia we can begin to appear at techniques of establishing medicines that could have the very same impact as restoring Pax5 function,” he explained.
Leukaemia researchers discover genetic switch to fix cancer cells in mice
11 Haziran 2014 Çarşamba
Retina grown from stem cells could permit blind to see once again
The retina is the layer of photo-sensitive cells and neurons at the back of the eye that converts light signals into nerve messages transmitted to the brain.
In the course of the experiment, Dr Canto-Soler’s crew had been capable to motivate initial growth of the retina, which then continued building on its own.
“When we started this work, we didn’t think stem cells would be ready to create up a retina virtually on their own,” Dr Canto-Soler said. “In our technique, somehow the cells knew what to do.”
At a stage equivalent to 28 weeks of foetal growth, the scientists tested the mini-retina by exposing it to pulses of light. They found that the lab-grown photoreceptors responded to light the same way as they do in the human eye.
Dr Canto-Soler, whose analysis is published in Nature Communications, said the method opened up the likelihood of generating hundreds of mini-retinas at a time from a man or woman impacted by blinding diseases.
These could be utilised to examine the triggers of retinal ailments in human tissue, rather than relying on animal versions.
Medicines tailored to personal patients could also be examined on the structures. In the prolonged term, diseased or dead retinal tissue could be replaced by laboratory-grown cells to restore vision, Dr Canto-Soler extra.
Age-relevant macular degeneration, which is induced by a dilemma with the retina, is the major cause of visual impairment in the United kingdom, affecting up to 500,000 men and women, according to NHS figures.
It is most frequent in folks more than 50, with one in ten people in excess of the age of 65 thought to be struggling from the issue to some extent.
Retina grown from stem cells could permit blind to see once again
23 Mayıs 2014 Cuma
A New Tick-Borne Parasite That Invades Red Blood Cells: Beware Babesiosis
Picture microscopic parasites that invade your red blood cells. This is the danger posed by Babesiosis, a little-recognized tick-borne sickness that the CDC has recognized as an emerging threat here in the U.S.
Comparable to malaria, Babesiosis is caused by microscopic protozoa called Babesia which can reproduce within red blood cells. Most situations of Babesia infection are induced by Babesia microti, but another type, Babesia divergens, has also been recognized and may possibly cause even much more significant condition. Two sorts of ticks, deer ticks and blacklegged ticks, can carry Babesia parasites.
But here’s the huge difficulty: it’s the nymph stage of the tick that is most regularly responsible for transmitting this parasite. And the nymph stage of a deer tick is very, extremely small – about the size of a poppyseed, according to the CDC.
You’re most most likely to get Babesiosis from the miniscule nymph-stage tick on the left. (Photograph: CDC)
Prolonged a well-acknowledged ailment in animals, notably cattle, Babesiosis was only spotted in humans as recently as the late 1950s and 1960s. Here in the U.S., Babesia was confined to quite specific regions such as Nantucket Island, but in the past handful of years it is been identified in a wider and wider spread across the country.
The place Is Babesiosis Most Frequent?
The bulk of cases of babesiosis reported just lately have been in the Northeast and upper Midwest states. New Jersey, New York, other components of New England, Wisconsin, and Minnesota have been the hardest hit, but just lately situations have been reported across the West and in Kentucky and Missouri. Wisconsin issued a health alert for Babesiosis in March. In California, but one more variety, Babesia duncani, has lately been identified as accountable for some of the reported cases.
Babesiosis-carrying ticks have a certain fondness for coastal areas, wetlands and marshes, and lake shores. In addition to Nantucket, experts have issued warnings for a lot of other well-known holiday spots such as Martha’s Vineyard, Fire Island, Shelter Island, Block Island close to Providence, and the east side of Long Island. At the youthful nymph stage in the course of which a tick is most very likely to transmit babesiosis, it is likely hunkered down in brush, grass, or wooded undergrowth.
When to Be concerned: Now Tick Season Is Just Beginning
Might is Lyme Disease Awareness Month for excellent explanation ticks are everywhere appropriate now. When it comes to threat of babesiosis infection, peak months are the warmest, normally from June by way of early October. And of course we’re out strolling our canines, hiking, cycling and camping far more in the course of these months, providing ticks lots of odds to hitch a ride.
Who’s At Chance?
Any individual can get babesiosis, and of program the much more you’re outdoors in at-chance areas, the far more publicity you have. Nevertheless, a powerful immune method can battle off the parasites, and many individuals will expertise only mild signs and symptoms or none at all. In fact, you might never even know you had been exposed.
These most at chance are the elderly, and these with compromised immune techniques this kind of as men and women with HIV or cancer sufferers on immuno-suppressive medicines. You are also at significantly increased chance if you have liver or kidney ailment or have had your spleen eliminated.
In accordance to Columbia University’s extensive report, Babesiosis can be fatal in up to twenty % of men and women with this kind of immune-compromising problems.
How Do You Know You have Been Exposed to Babesiosis?
Unfortunately, often you don’t. This is simply because the tick bite that transmits this parasite is so little think about the minuscule bite mark left by a nymph-stage tick that is itself the size of a pinhead. So rather, it is symptoms that are most very likely to alert you. And you want to recognize them as early as feasible, as babesiosis can be extremely unsafe as soon as it progresses.
A New Tick-Borne Parasite That Invades Red Blood Cells: Beware Babesiosis
13 Mayıs 2014 Salı
New brain cells could wipe away previous memories, examine finds
“The locating was very surprising to us at first. Most men and women think new neurons indicate better memory,” mentioned Sheena Josselyn, a neuroscientist from the Hospital for Sick Children in Toronto, who led the research.
Right up until now, numerous scientists have imagined long-phrase memories may possibly be tied to language simply because young children normally start off forming lengthy-phrase recollections at about the same time they start off talking.
“But the really weird factor is that most animals display infantile amnesia too,” said Josselyn.
“So the improvement of language can not be the total explanation.”
Inspired by observations of their personal toddler, Josselyn and her husband, examine coauthor Paul Frankland, started to query why young kids could not retain memories of scenarios or occasions.
The recollections involve the hippocampus, the only part of the brain which normally generates new neurons, which scientists feel is vital to make recollections.
But the manufacturing of these new cells tapers off in childhood.
“That’s precisely when we begin to be capable to kind prolonged-term recollections,” Josselyn explained.
Her research of mice, which like people fail to retailer early memories, showed the decline in the production of new neurons as the rodents grew up matched their capability to keep in mind frightening conditions.
Josselyn explained: “More neurons improve the capacity to learn new recollections in the potential
“But memory is based on a circuit, so if you add to this circuit, it helps make sense that it would disrupt it.”
She believes the newly additional neurons could have a beneficial position in clearing old recollections and creating way for new ones.
New brain cells could wipe away previous memories, examine finds
5 Mayıs 2014 Pazartesi
Stem Cells May Restore "Irreversible" Heart Harm
In December 2011, I reported on a single of the initial attempts to inject stem cells into broken hearts. In that study, published in The Lancet, scientists grew stem cells from patients’ own hearts following the sufferers had suffered serious heart attacks. These have been individuals who had severe, irreversible heart injury. As the study leader, Dr. Roberto Bolli, said at the time,
“Once you reach this stage of heart condition, you really do not get much better. You can go down slowly, or go down rapidly, but you’re going to go down.”
Amazingly, in that review, the patients got much better. 14 of the 16 sufferers had enhanced heart function after four months, and the results were even better after one year. The stems cells grew into new, working heart cells.
Ailments and circumstances where stem cell treatment is promising or emerging. Now we can include heart disease to the list. (See Wikipedia:Stem cell#Remedies.) Model: Mikael Häggström. (Image credit score: Wikipedia)
That was just a single examine. Now there have been far more, and the outcomes proceed to be really encouraging. Just last week, the Cochrane Collaboration published a assessment of 23 trials, all of them trying stem cell therapy for heart disease. These trials looked at the use of bone marrow stem cells in individuals whose hearts have been failing. In contrast to the 2011 examine, which looked at heart assault individuals, these scientific studies looked at sufferers with innovative heart ailment who had not suffered a heart assault. The benefits: total, stem cell remedies decreased the chance of death and improved heart perform, however the benefits had been not as dramatic as in the individuals with heart attacks.
What is most interesting in the newest studies is the lengthy-term reduction in the threat of death. 6 of the studies reported prolonged-phrase final results (a lot more than 1 year) on mortality. In these scientific studies, 8 patients died out of 241 who acquired stem cell therapy (three.3%). In contrast, 30 sufferers died out of 162 (18.five%) who did not acquire stem cells. The numbers are small, but this is a huge benefit: individuals have been about 5 occasions less very likely to die. The Cochrane assessment concluded that
“The danger of mortality above long-phrase adhere to-up was significantly reduced for people who obtained BMSC [bone marrow stem cell] treatment.”
An critical caveat is that this is nonetheless “low quality” evidence, which means that we want to see much more information, on many much more individuals, just before we can have self-confidence in the outcomes. But it is nevertheless extremely encouraging, especially when no other treatment offers anything remotely this promising for innovative heart illness.
The proof continues to construct that stem cells can repair heart tissue damaged by heart attacks. Just a couple of months ago, Britain launched the biggest review yet of stem cell therapies for heart attacks, involving 3,000 patients in Europe. This new evaluation shows that they can help repair some of the damage from other kinds of heart disease as well.
Heart condition is the foremost result in of death in the United States, and we need to be pursuing every plausible treatment, even though quite couple of exist. Stem cells provide the hope that, for the first time ever, we might be able to reverse heart harm that was previously considered to be irreversible. Stem cell treatments are a real breakthrough, and rather than cutting health-related investigation, as we have been doing for the previous 5 many years, we should be pouring sources into this exceptional new healthcare technologies and the therapies that it can make attainable.
Stem Cells May Restore "Irreversible" Heart Harm