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16 Mart 2017 Perşembe

Meditation’s Benefits Proven Further By Mindful Mice

Anecdotal evidence has for decades suggested that the regular practise of meditation has a profound physical and psychological benefits, and in recent years human studies have provided solid scientific confirmation to these suppositions. From physical brain changes to lessened anxiety, the human participants in these studies have experienced measurable benefits. For additional proof, researchers have extended their studies to mice.


By using light to trigger brain activity similar to that seen in humans when they are meditating, Michael Posner of the University of Oregon believes he’s created the first ever meditating mice. Having previously discovered that meditation changes the white matter in the brains of human volunteers, Posner hypothesised that theta brainwaves are responsible for the adjustment.


Measured using electrodes attached to the scalp, theta brainwaves increase in meditators, even when they are in a non-meditative state. The changes this appears to induce in white matter relates to communication between the different brain regions and are particularly noticeable in the ACC, or anterior cingulate cortex.


With the ACC area of the brain regulating the amygdala – which is responsible for our response to fear response – Posner has concluded that alterations in the ACC bring about the positive effect meditation has for people suffering from anxiety.


In order to gain further understanding, Posner undertook the task of creating an animal model of meditation which would allow his team to make new observations. In order to mimic the theta brainwave changes discernable in humans, he used a method known as optogenetics.


A technique in which scientists genetically engineer certain brain cells to be stimulated by light, optogenetics allowed the researchers to induce increased theta brainwave-like activity in the mice. Having received half an hour of this mental stimulation for 20 days, the mice’s behaviour was examined to see whether there was any discernable change.


Attempting to ascertain whether the anxiety levels in mice had changed after this meditation-like activity, they were placed in boxes with areas of light and dark. Frightened mice will not leave the dark areas, and in this way the scientists found out that the “meditating” mice were less anxious than their non-meditating counterparts.


The researchers have yet to conclusively investigate the white matter of these mice, but these early indications of behavioural changes bodes well for research into meditation in the future. It also adds credence to the idea that meditation itself – rather than the relaxation it provides or a placebo effect – can be an effective and scientifically valid way to treat mental health issues such as anxiety.



Nick Huxsted

Nick Huxsted works for Will Williams Meditation in London. Their aim is to help people live the happiest, healthiest lives they can through the ancient practice of Vedic meditation.



Meditation’s Benefits Proven Further By Mindful Mice

10 Mart 2017 Cuma

Meditation’s Benefits Proven Further By Mindful Mice

Anecdotal evidence has for decades suggested that the regular practise of meditation has a profound physical and psychological benefits, and in recent years human studies have provided solid scientific confirmation to these suppositions. From physical brain changes to lessened anxiety, the human participants in these studies have experienced measurable benefits. For additional proof, researchers have extended their studies to mice.


By using light to trigger brain activity similar to that seen in humans when they are meditating, Michael Posner of the University of Oregon believes he’s created the first ever meditating mice. Having previously discovered that meditation changes the white matter in the brains of human volunteers, Posner hypothesised that theta brainwaves are responsible for the adjustment.


Measured using electrodes attached to the scalp, theta brainwaves increase in meditators, even when they are in a non-meditative state. The changes this appears to induce in white matter relates to communication between the different brain regions and are particularly noticeable in the ACC, or anterior cingulate cortex.


With the ACC area of the brain regulating the amygdala – which is responsible for our response to fear response – Posner has concluded that alterations in the ACC bring about the positive effect meditation has for people suffering from anxiety.


In order to gain further understanding, Posner undertook the task of creating an animal model of meditation which would allow his team to make new observations. In order to mimic the theta brainwave changes discernable in humans, he used a method known as optogenetics.


A technique in which scientists genetically engineer certain brain cells to be stimulated by light, optogenetics allowed the researchers to induce increased theta brainwave-like activity in the mice. Having received half an hour of this mental stimulation for 20 days, the mice’s behaviour was examined to see whether there was any discernable change.


Attempting to ascertain whether the anxiety levels in mice had changed after this meditation-like activity, they were placed in boxes with areas of light and dark. Frightened mice will not leave the dark areas, and in this way the scientists found out that the “meditating” mice were less anxious than their non-meditating counterparts.


The researchers have yet to conclusively investigate the white matter of these mice, but these early indications of behavioural changes bodes well for research into meditation in the future. It also adds credence to the idea that meditation itself – rather than the relaxation it provides or a placebo effect – can be an effective and scientifically valid way to treat mental health issues such as anxiety.



Meditation’s Benefits Proven Further By Mindful Mice

16 Aralık 2016 Cuma

The social care crisis is pulling NHS trusts further underwater

The government’s refusal to find any new money for social care will inflict significant and lasting damage on the NHS and the lives of its patients.


The local government finance settlement announced by the communities secretary, Sajid Javid, this week did virtually nothing to alleviate the growing social care crisis. He simply allowed local authorities to bring forward council tax increases and shifted £240m from housing.


Compare that with Local Government Association figures showing adult social care funding fell from £14.7bn in 2012-13 to £14.1bn in 2015-16, while demand continues to rise.


The government’s refusal to provide any meaningful relief for social services is a blow to the NHS England chief executive, Simon Stevens. Ministers have been unshakeable in their insistence that they have given the NHS more than it asked for to fund the Five Year Forward View transformation plan, a position that Stevens has directly challenged in parliament. With no likelihood of the health service getting more money directly, Stevens had been pushing hard to get additional cash into health and care through social services. That has now failed.




Safe occupancy levels are now breached routinely, increasing the risk of hospital-acquired infections




The health and care system is now in a stand-off with the government. Downing Street sees constant calls for more money as no more than routine shroud-waving, and suspects that the Sustainability and Transformation Plan initiative will provide more of the same. Javid and the health secretary, Jeremy Hunt, are locked into this position, whatever their private views.


For many trusts, the social care crisis is pulling them further underwater. Managers tell of the equivalent of several wards of patients stuck in their hospital for want of social services. Some trusts are beginning to invest in stepdown care themselves to alleviate the pressure.


The Nuffield Trust, in its analysis of hospital bed occupancy, points out that delays in discharging medically fit patients from hospital are at a 10-year high. Keeping people waiting in A&E for a few minutes longer than four hours can be headline news, but the scandal of thousands of people being stranded in hospital for days receives far too little political and public attention.


Safe occupancy levels are now breached routinely, increasing the risk of hospital-acquired infections and causing patients discomfort and distress as they are shunted from ward to ward. Although high bed occupancy has a number of causes, delayed discharges through shortfalls in social care are a substantial factor.


Dangerously high bed occupancy breeds a sense of crisis in a hospital, with temporary beds being set up, staff being redeployed, and the daily, unwinnable battle to get people in and out of a ward distracting nurses from patient care. For A&E staff, the difficulty of getting patients on to wards creates yet more stress.


But ultimately the issue is not budgets or bed occupancy rates, it is the human rights and welfare of thousands of mainly elderly people forced to stay in hospital against their will. Delayed discharge is not merely an inconvenience; it can be life-changing.


Each day in hospital can chip away at a person’s confidence in their ability to return home and live independently. Continence management in hospitals is often poor, causing people to acquire another – and particularly distressing – condition even as they are being treated for a different one. Disorientation increases the longer people are away from their own homes, particularly if they have dementia.


So, too often, the inability of the health and care system to get people out of hospital as soon as they are ready, and get them back in their own homes with the right support, means a substantial reduction in their quality of life. Too often this includes a move to a care home that should never have happened.


Elderly patients stuck in hospital are the unwitting hostages in the battle for money between the government, the NHS and local authorities. The prime minister and chancellor’s unbending approach to health and care funding is being played out in the deterioration in the quality of life of thousands of mainly elderly people.


Join the Healthcare Professionals Network to read more about issues like this. And follow us on Twitter (@GdnHealthcare) to keep up with the latest healthcare news and views.



The social care crisis is pulling NHS trusts further underwater

10 Ekim 2016 Pazartesi

Nine ways funding for the global HIV response could go further

1 | Protect and promote human rights


Public resources are wasted on enforcing laws that criminalise HIV transmission and dehumanise at-risk populations. By contrast, laws that protect at-risk populations are powerful, low-cost tools that help ensure that financial and scientific investments for HIV are not wasted. Enacting laws based on sound public health and human rights will ensure new prevention and treatment tools – such as PrEP [pre-exposure prophylaxis], male circumcision and microbicides – reach those who need them. Changes in the legal and policy environment, along with other interventions, could lower new adult HIV infections to an estimated 1.2 million by 2031 (compared to 2.1 million if current efforts continue unchanged). Mandeep Dhaliwal, UNDP


2 | Make drugs cheaper


One way to make limited funds go further is to challenge drug companies on the high price of life-saving drugs. The use of unmerited patents by pharmaceutical companies to secure monopolies on their products must stop. Make Medicines Affordable is working with civil society to challenge unmerited patents and use Trips agreement flexibilities. Julia Powell, International Treatment Preparedness Coalition


In lower middle-income countries, the average antiretroviral (ARV) treatment cost for a new adult patient is around $ 350 [£283]. Of that, just 40% is the cost of the ARV – 35% is non-ARV recurrent costs (clinical salaries, laboratory etc) and then 25% is programme management. We really need to dissect non-drug costs and find ways to reduce costs with regard to generic licensing and optimising manufacturing costs. Anand Reddi, Gilead Sciences


3 | Support LGBT groups


There are some great new global funds supporting funding for local and national LGBT groups so that they can gather data on access to medicines for their community, in a way that ensures their confidentiality and safety. The Rapid Response Fund, funded by the Elton John Aids Foundation (EJAF), the President’s Emergency Plan for Aids Relief (Pepfar) and UNAids, will support civil society organisations that are led by, or work closely with, MSM [men who have sex with men] and LGBT people and communities, to implement rapid responses to situations or events that threaten their access to HIV services. Grants of up to $ 20,000 [£16,000] are available. Mike Podmore, STOPAIDS


4 | Support adherence to ARVs


Drug resistance is a huge issue and one to which we are only just waking up. The World Health Organisation has produced a 2017-21 action plan which, I think, underlines that we have neglected to focus on adherence and support people not just to access ARVs, but to stay on them. Mike Podmore


5 | Integrate HIV into health sectors


Finance ministers tend to think in terms of sectors (eg health) or a clusters of sectors (eg the social sectors – education, health, social welfare), rather than in terms of individual issues like HIV. We need to integrate Aids financing into domestic health financing and make the argument to finance ministers that they need to increase investment in the social sectors, and health in particular. We need to underscore why this is an important investment in human capital and, therefore, in economic development. David Wilson, World Bank


6 | Collect and spend taxes on health


Some countries with major HIV epidemics have actually progressively reduced the share of the government budget they allocate to health, and many African countries with major HIV challenges collect a smaller share of GDP as revenue – and spend more collecting that small share – than comparable economies elsewhere. We must ensure that a significant share of the greater revenue collected is allocated to health, and spent as efficiently as possible. David Wilson


7 | Integrate HIV and water and sanitation programmes


Safe water can make an enormous difference to the health and wellbeing of people living with HIV. It can increase drug effectiveness by reducing diarrhoea and collaboration between HIV specialists at Safaids and in the water and sanitation sector have identified ways to integrate water and HIV programming more effectively in southern Africa to streamline investments. In addition, a recent systematic review showed that water and sanitation interventions to reduce morbidity among people living with HIV were cost-effective, particularly when incorporated into complementary programmes. Louisa Gosling, WaterAid


8 | Coordinate responses


In the HIV/Aids space, we can work with others focusing on health to share costs. In Malawi, for example, our mobile clinic teams test and treat for malaria and TB even though our core focus is HIV. Also, in our door-to-door testing pilot – where a team of eight canvases a village over a week to perform HIV tests – that same team will check for bed nets. If they do not have one, our HIV testing team will leave one and teach the family how to use it. One team, but two major health issues covered. Joel Goldman, The Elizabeth Taylor AIDS Foundation


9 | Push for more funding


We must reject the assumption that we will/can have less money and, instead, make it clear that less money, or even maintaining the same levels of funding, will lead to an increase in infections and deaths globally. Many organisations working on the global HIV and TB responses are shouting loudly about the funding alarm. It became even more urgent when the Kaiser Family Foundation found that global donor financing had reduced by 13% from 2014 to 2015. Our only way forward is to increase general public awareness and demand for donors and INGOs to increase HIV and TB funding up to 2020, and make it possible to end the epidemics by 2030. If not, we risk a terrifying rebound of the epidemics that we will struggle to get a grip on again. Mike Podmore


Read the full Q&A here.


Join our community of development professionals and humanitarians. Follow @GuardianGDP on Twitter.



Nine ways funding for the global HIV response could go further

12 Ağustos 2016 Cuma

Junior doctors consider further strikes in contract dispute

Junior doctors are considering further strikes in September after rejecting the health secretary Jeremy Hunt’s proposed new contract.


Ellen McCourt, who chairs the British Medical Association’s (BMA) junior doctors committee, said that by standing together they could demand the government takes them seriously.


Strikes took place between January and April after junior doctors failed to come to an agreement with the government. In July the government announced it would impose a contract after junior doctors and medical students voted to reject a deal brokered with the BMA.


In a letter to members released on Thursday night, McCourt said the government had remained “persistently silent” on the issues she said had led to the rejection of the contract.


— #hellomynameisEllen (@McCourtEllen) August 11, 2016

The road ahead will not be easy,by standing together we speak with one voice,our unity remains our strength @TheBMA pic.twitter.com/DAuXhf5fjS



She said: “In light of this, the JDC executive has voted to reject the proposed new contract in full and to call for formal renegotiations on all of your concerns.


“In response to the government’s silence, JDC exec has today made a formal request for a special meeting of BMA council to authorise a rolling programme of escalated industrial action beginning in early September.”


She said the BMA could not stand idly by as the date for imposition drew nearer, and argued that forcing a contract on doctors that they did not have confidence in would be bad for patients.


Daniel Mortimer, the chief executive of NHS Employers, said: “Industrial action achieves little or nothing but places pressure on already stretched teams and services and causes worry, distress and disruption for patients, carers and their families.


“Over the last two months we have been talking with the junior doctors committee and have, along with the Department of Health and others, responded positively to their concerns regarding the guardian role and whistleblowing.”


He said employers were serious about “positive engagement” with the BMA.



Junior doctors consider further strikes in contract dispute

5 Temmuz 2014 Cumartesi

4 in ten assistance paying out much more tax if further goes to NHS

protesters against NHS cuts march in London

Protesters towards NHS cuts march in London last month. With specialists predicting massive yearly shortfalls by 2020, a new NHS tax has been proposed as a wayto fill the gap. Photograph: Paul Davey/Demotix/Corbis




More than 4 out of 10 voters – such as above half of these who assistance Labour – would be prepared to pay a lot more in tax if they knew the further income would go to the NHS.


An Opinium/Observer poll discovered 43% of folks would be prepared to pay larger taxes specifically for wellness care 53% of Labour voters would be willing do so, against 36% of Tory supporters.


The survey showed really sturdy help for keeping the present rule that NHS therapy need to stay totally free at the stage of delivery, with 77% agreeing that this must proceed to be the case, irrespective of the price to taxpayers, in contrast with only 6% who disagreed.


With many specialists predicting that the NHS will face large annual funding shortfalls by 2020 unless added funds is pumped in, there is escalating debate at Westminster in excess of whether or not a new “NHS tax” is required, and would win public help.


1 thought getting examined by Labour is to increase national insurance contributions to develop a specific fund, the proceeds of which would be focused to supplying well being and social care solutions.


Top Tories, which includes former overall health secretary Stephen Dorrell, and Sarah Wollaston, the Conservative MP for Totnes and new chair of the well being pick committee, have mentioned investing on wellness will have to rise in actual terms in the up coming parliament if solutions are to be maintained.


Latest figures primarily based on data from NHS England and the Nuffield Trust recommend that NHS charges alone will go from £95bn a yr now to much more than £130bn a year by 2020.


The public appeared a lot more resistant to the concept of paying out some sort of membership charge for the NHS with just 32% supporting the idea, against 42% who opposed it.


state of the parties Intention of people most likely to vote Photograph: Guardian



The poll place Labour six points ahead of the Conservatives with just 10 months to go until the next basic election. Labour is on 35% (up 2 factors on a fortnight in the past), although the Tories are on 29% (-2), Ukip 18% (+1), the Lib Dems seven% (n/c) and the Greens 5% (n/c).


David Cameron’s private rating has dropped because the final poll by five points to -15% (individuals who approve of his performance, against individuals who disapprove) while that of Labour leader Ed Miliband is unchanged on -26%.


NHS poll in pie charts The poll benefits in full. Photograph: Guardian




4 in ten assistance paying out much more tax if further goes to NHS

15 Mayıs 2014 Perşembe

Stephen Sutton"s legacy to consist of further beds and nurses for teenage cancer individuals

His JustGiving webpage broke all information for the website, like the most funds raised by an individual and the most donors – more than 162,000 – who have sent money from 94 different nations from Andorra to Zimbabwe.


The Teenage Cancer Trust stated these days that the cash raised by Stephen would go to assisting the seven younger people diagnosed with cancer each day in the United kingdom.


His legacy will incorporate building new Teenage Cancer Trust units in hospitals, exactly where expert beds and widespread rooms will be supplied for sufferers aged 13 to 24. The cash will also be utilised to pay for additional teenage cancer professional nurses and youth support staff in hospitals.


A spokesman for the charity said: “Donations made to Stephen’s Story will be spent on supporting and building our vitally critical providers created to assist the 7 young folks, like Stephen, who are diagnosed with cancer each day.


“This involves the advancement of new Teenage Cancer Trust units as properly as supporting our existing network of 28 units in NHS hospitals across the United kingdom. We will also be in a position to enhance the variety of expert nurses and youth help coordinators we give, as properly as keep our schooling operate.”


Teenage Cancer Trust units guarantee that youthful men and women are handled alongside folks their personal age, by nurses who specialise in the healthcare and emotional requirements of teenage cancer individuals. With out the charity’s work, sufferers beneath the age of 16 would be taken care of on children’s wards, alongside toddlers, although in excess of-16s would be on adult wards, alongside pensioners, in line with NHS policy.


The units can value anything at all from £250,000 to much more than £3 million, based on the variety of beds and no matter whether an current ward is refurbished or an entirely new developing is needed.


The charity money 27 specialist nurses and 21 youth assistance co-ordinators, who are all primarily based in NHS hospitals. The 28 Teenage Cancer Believe in units in England, Scotland and Wales have all around 220 beds, though numbers vary based on demand. The units also have common rooms with computers, pool tables and other actions the place individuals can meet every other and socialise.


The Nationwide Institute for Clinical Excellence (Nice) has endorsed the TCT model as the best way of caring for teenagers and young adults with cancer.


Stephen, of Burntwood, Staffs., was taken care of in a Teenage Cancer Trust unit at the Queen Elizabeth Hospital in Birmingham, exactly where he eventually died.



Stephen Sutton"s legacy to consist of further beds and nurses for teenage cancer individuals

9 Mayıs 2014 Cuma

Hospitals need to have thousands of further nurses "or patients" security will be at risk"

Nursing levels at one trust were estimated to be 100 nurses short of the number to ensure safe care

Staffing ranges at 1 believe in have been estimated to be 100 nurses brief of the quantity required to promise safe care for sufferers. Photograph: Christopher Furlong/Getty




Nurses should not have to appear right after a lot more than eight sufferers in hospital at one time, the body that sets NHS specifications will urge next week in a move that will enhance the strain to end what critics declare is dangerous understaffing.


Responding to the worries about specifications of patient care in the aftermath of the Mid Staffs scandal, the Nationwide Institute for Health and Care Excellence (Good) will warn that registered nurses’ workloads should not exceed that variety since patients’ security could be at risk.


The regulator’s intervention will intensify the pressure on hospitals, increasing numbers of which are in financial difficulty, to retain the services of much more workers to tackle shortages even though a lot of have quite small spare income. Campaigners on the subject believe least 20,000 extra nurses are urgently essential at a price of about £700m.


It will also pose a challenge to ministers, who till now have resisted calls for the NHS to introduce probably pricey mandated minimal staffing levels.


In drawing up the new advice, Nice has accepted a lot of of the major arguments place forward by groups such as the Risk-free Staffing Alliance, which has been campaigning for a ratio of no much more than one nurse to eight adult inpatients.


Good, an authoritative entire body whose recommendations are supposed to be implemented across the NHS, has spent months examining evidence on the affect workers numbers have on each the quality and the security of the care sufferers receive.


Ministers expanded the remit of Good, which is greatest recognized for choosing which medication signify value for funds for the NHS, and asked it to make suggestions on protected staffing amounts after last year’s Francis report into the Mid Staffs scandal. It found that understaffing at Stafford hospital, induced by expense-cutting by the trust, had contributed immediately to what a preceding official inquiry referred to as “appalling care” which led to patients dying and suffering critical harm.


Professor Gillian Leng, Nice’s deputy chief executive, is anticipated to say that hospitals should not see Nice’s new recommended 1:eight ratio as a straitjacket, but that failure to observe it and overloading nurses threat harming sufferers.


Leng will also tell hospitals that nurses require to be continually on the alert for “red flag events”, such as patients not receiving support to go to the bathroom or not getting ache medicine, which can trigger an immediate want for far more nurses on the wards.


Susan Osborne, the chair of the Safe Staffing Alliance, which contains the Royal College of Nursing (RCN), the overall health union Unison and the Individuals Association, welcomed Nice’s move as progress in the direction of ideal staffing amounts. Individuals could die if it was not observed, she warned.


“A 1:eight ratio still indicates that the nurse only has 7 and a half minutes per patient per hour, which is also minor. If it really is much more than eight then patients will not get fed, care plans will not get written, and nurses cannot sit and speak to sufferers and reassure them about their condition. Care just won’t be offered to a suitable common, and individuals can die,” explained Osborne, a former director of nursing at St Mary’s hospital in west London.


Eight need to be the absolute highest quantity of patients a nurse must have to care for but “if you get to that degree it truly is bordering on unsafe care”, so ideally the ratio should be one:4 or one:six, she additional.


The RCN has been warning that the developing number of medically complex sufferers in hospital since of the ageing population and lengthening lifespans means that nurses are beneath “untenable and unsafe” pressures. In a report final November it estimated that the NHS necessary 20,000 a lot more nurses. Some hospitals have up to sixteen% of their nursing posts vacant, RCN freedom of details requests located.


A lot of hospitals shed staff from 2010 in an try to make savings and comply with the £20bn, four-12 months Nicholson Challenge. Despite the fact that numerous have begun hiring much more nurses because the Francis report, shortages are typical and recruitment from overseas countries such as Spain, Portugal and Ireland is increasing.


At one particular trust alone, which lately asked Osborne to assess its nurse staffing ranges, she concluded that it was 100 nurses quick of the variety needed to guarantee protected care for patients and that they would expense £3.5m to recruit.


Even so, several trusts are locating it hard to recruit nurses locally and are increasingly bringing in personnel from overseas. “Given that Mid Staffs they have made the decision to devote money to get far more nurses and they are recruiting like crazy but there are nonetheless major shortages,” stated a single NHS nursing professional. Trusts unable to discover everlasting employees are paying hundreds of hundreds of thousands of pounds a yr on bank and agency nurses to plug gaps in nursing rotas.


David Loughton, chief executive of New Cross hospital in Wolverhampton, not too long ago estimated that it would take his trust among 18 months and two and a half many years to recruit the quantity of workers it needed. It planned to deliver in 135 additional nurses, so that each and every shift on every single ward would have one particular additional nurse.


The Division of Health declined to comment just before Good publishes its guidance on Monday.


Labour is most likely to challenge the government to say regardless of whether it will accept the recommendation from the authorities. The celebration has lately pointed out that thousands of nursing and other frontline jobs have been axed considering that the election, even though a single in six hospitals in England have not too long ago failed inspections on the grounds of inadequate personnel numbers.




Hospitals need to have thousands of further nurses "or patients" security will be at risk"

10 Nisan 2014 Perşembe

Government invested further £49m on Tamiflu despite known doubts about it

Tamiflu tablets

Antiviral drug Tamiflu tablets made by Roche Pharmaceuticals. Photograph: Per Lindgren/REX




The government has spent an further £49m inside of the last 12 months on renewing its stockpile of Tamiflu, the drug which independent scientists say could do nothing at all to avert a flu pandemic.


The decision to spend however more funds on a stockpile of controversial medicines that has already price above £500m “verges on the reckless, given that the proof base was presently extremely shaky”, according to Richard Bacon, Conservative MP and senior member of the public accounts committee.


The revelation of the additional spending came in the government’s response to the committee’s report in January, which recommended that no a lot more Tamiflu should be purchased till the Department of Well being had reviewed the need to have for it.


At the time, the committee was informed the division had invested £424m on Tamiflu and £136m on a equivalent, but inhaled, flu drug known as Relenza. The extra £49m will take the total invest to £609m.


On Thursday, independent scientists from the Cochrane Collaboration published an examination of all the data from the clinical trials carried out by manufacturers Roche and GlaxoSmithKline prior to licensing of the medication, which took them above four many years of negotiations to acquire.


They concluded that the medication shorten a flu bout by approximately half a day, but there is no evidence that they avoid hospitalisations or complications such as pneumonia and, when utilised to avert flu, they cause some men and women significant problems like psychiatric and kidney difficulties.


The organizations keep the drugs are risk-free and beneficial, but Bacon says the doubts about the drugs had been evident at the time of his committee’s inquiry final yr, ahead of the further £49m had been invested. A important member of the Cochrane staff gave proof. “You do not devote £400m to decrease flu signs by a day or half a day. You buy Lemsip for that. You commit millions of pounds on it to avert pandemic flu,” he advised the Guardian. “They must have held off and waited till the more analysis was available.”


In its response to the PAC report, the government explained that the 2013-14 programme to replace drug stocks going out of date with new batches was currently in location. The selection to go ahead “supports the department’s dedication to be prepared for a more serious influenza pandemic and to pay the prices agreed in the current contract.”


The government also dismissed calls by the committee for all clinical trials – past and potential – to be registered and the information from them created available for wider independent scrutiny, saying it was “not feasible” to do it retrospectively.


“What is wrong with opening it up to wider independent scrutiny?” asked Bacon. “Are we to believe the perform undertaken by regulators has some kind of magic charm about it and that there is a priestly caste referred to as government-appointed scientists who have obtainable to them insights that are not available to other individuals? Are they asking us to go back to the 13th century or the 16th century or back to alchemy? Is this what they want? That’s what it sounds like to me and I feel it is ridiculous.”


A developing variety of senior scientists feel the issue lies with the piecemeal way in which clinical trials are completed. They are not set up to reply distinct concerns that are of agreed worldwide crucial, such as, in the situation of Tamiflu, exactly what problems it can avoid and what use it would be in a pandemic.


Jeremy Farrar, director of the Wellcome Trust and a professor of tropical medication at Oxford University, mentioned regulators, scientists, medical doctors, policymakers and other individuals concerned in drug advancement have to come together to work out what the vital queries are that require to be answered, so that when there are many trials, usually of broadly comparable medication, the benefits can be aggregated for a clear image of what works and what does not. On Tamiflu, he stated, “the trustworthy reality is we merely do not know”, because the trials have been not made to look for the appropriate solutions.


We could find out from the approaches that have been taken to ailments in poor countries, such as malaria and HIV, he stated, in which employing income and time value-efficiently to come to the right answers is vital.




Government invested further £49m on Tamiflu despite known doubts about it

11 Mart 2014 Salı

Cancer"s hidden price tag tag: misplaced earnings, further costs and higher bills

price tag

Cancer individuals are faced with a reduction in earnings, added charges and an increase in day-to-day costs. Photograph: Martin Argles for the Guardian




Cancer is an expensive disease. It is not only a healthcare concern but it also threatens someone’s finances, the influence of which can often outlive the diagnosis itself. Macmillan study demonstrates 4 fifths of men and women living with cancer are hit with an average expense of £570 a month as a result of their diagnosis. But for some this price is substantially higher and can run into the thousands.


Why is cancer so costly? A blend of a reduction in earnings, additional expenses, such as travel and parking, and a rise in the expense of day-to-day residing indicates that, in a hard financial climate, cancer individuals are now faced with the two a bodily and monetary fight.


Get Mario, for instance. When he was diagnosed with non-Hodgkin lymphoma he became too ill to perform and could no longer run his restaurant. The sudden additional costs of heating his residence and travelling to hospital, combined with a dramatic reduction of revenue, meant he could not pay out his expenses and ended up shedding both his home and his enterprise. Mario moved into council housing and necessary to claim rewards just to pay for basic wants such as foods. At a time when he ought to have been focusing on his recovery, Mario was instead left on the brink of poverty.


Decreased income is the most significant single cause of economic reduction for people residing with cancer. This is due to the fact numerous will need to drop out of work to undertake what is usually gruelling medical treatment. A third of people will drop £860 a month as a end result of not becoming capable to function several will struggle to adequately heat their properties, feed themselves, travel to appointments or pay out for childcare.


What’s much more, a lack of support from their employers can make it harder for patients to return to their jobs – even if they are willing and able to do so. This not only pushes them more into debt, but signifies they are far more dependent on welfare for monetary protection, putting the technique of state support beneath further strain.


So what demands to be accomplished to resolve this situation? Each sector has a portion to perform in reducing the monetary impact of cancer. The government and the NHS should do all they can to make sure that cancer individuals are offered fiscal details and assistance at the earliest achievable stage. The appropriate suggestions at the correct time can assist people handle their finances, access financial help, and in flip focus on their physical overall health. Not only does this enhance a person’s recovery and standard wellbeing, but it is probably to present lengthy-phrase cost savings to nationwide wellness and welfare infrastructures. For illustration, our proof exhibits that for each £1 invested in positive aspects suggestions, an further £19 is created.


Employers also want to do much more for cancer individuals. They need to have to aid their employees keep in and return to work in which they are ready to. They also require to greater realize their emotional and physical needs throughout or right after a cancer diagnosis.


Banks and insurance coverage businesses must also take steps to ease the monetary consequences for their buyers: making certain that personnel members are nicely educated, that items made for critical sickness are accessible, and that clients are assisted to control their monetary commitments.


To fail to get methods to handle the fiscal, emotional and social needs of cancer individuals is to fail to consider actions against cancer as a complete. Despite the fact that there are several much more areas to discover, options and measures are available now that we need to exploit to redress cancer’s hidden price tag.


Ciarán Devane is chief executive at Macmillan Cancer Help




Cancer"s hidden price tag tag: misplaced earnings, further costs and higher bills

18 Şubat 2014 Salı

Overall health thinktank urges further shakeup of GPs | Denis Campbell

Doctor giving baby polio vaccine

The report suggests GP practices join collectively to be ready to give individuals a wider selection of experience. Photograph: Alamy




GP practices need to begin working with each other in federations and delivering far much more providers in a restructuring of healthcare that is vital to hold the NHS sustainable, the King’s Fund urges today in a report that has attracted high-level government curiosity.


Key adjustments are needed in how major care and the two hospital and local community-based solutions are funded, delivered and co-ordinated so that the health support can cope with the large pressures caused by ageing and long-phrase conditions, the thinktank argues.


Its report on the potential of basic practice comes much less than a yr right after the coalition’s unpopular and far-reaching overhaul of the overall health services in England. It accepts that it would involve “a radical departure for the NHS” and nevertheless more upheaval, especially for GPs. But it contends that without having household medical doctors hugely expanding their roles – such as a controversial resumption of obligation for out-of-hours care – the NHS will fail to cope with rising demand, years of expected tight budgets and a expanding shortage of GPs.


If implemented, the suggestions could make the prolonged-sought integration in between health and social care that ministers agree is essential to extended-term sustainability, reverse basic practice’s diminishing share of the service’s £110bn spending budget and see many providers delivered outdoors hospitals – an additional big shift that, despite the fact that widely supported, has not but took place.


“We argue that GPs should take the lead in establishing care out of hospital by taking responsibility not only for their own solutions but for a lot of other providers used by sufferers in the local community”, say co-authors Professor Chris Ham, the thinktank’s chief executive, and Rachael Addicott, a senior fellow.


Ham says: “There needs to be a radically diverse model of common practice in the potential simply because of the ageing population and shifting burden of ailment, particularly the truth that more men and women have a lot more complex demands. And this kind of people are not getting effectively served by the current model of general practice, since what they require is not what their practice can show. What they need to have is accessibility to other skills and employees in the local community, such as community nurses, physiotherapists and occupational therapists, and also social care – and at times they require access to these services 24/7 rather than throughout surgical procedure opening hours. At the second, common practice is not sustainable.”


The essential to the report is the suggestion that in between 4 and 25 GP practices join up to turn into a federation, every of which covers amongst 25,000 and 100,000 individuals. They are the bodies that would be the hub of “loved ones care networks” (FCNs). Each and every would get a population-primarily based spending budget, but from a single of NHS England’s nearby area teams and not from the 211 neighborhood clinical commissioning groups (CCGs)designed by last year’s reorganisation. This raises significant questions more than the purpose and viability of CCGs, which had been meant to symbolise GPs currently being put in the driving seat of healthcare.


Even though patients would stay registered with their personal GP, Ham says FCNs would give them access to a a lot wider selection of experience than any practice can at present provide alone.


“I feel that above time CCGs would no longer be essential to commission care as they do these days, and would wither on the vine,” Ham admits.


In her foreword to the report, Dr Maureen Baker, chair of the Royal College of Basic Practitioners, factors out that it very first floated the thought of federations a decade in the past and that some currently exist, and operate efficiently. Nevertheless, Dr Chaand Nagpaul, chair of the British Health care Association’s GPs’ committee, says basic practice does not need yet another reorganisation: “As an alternative, we must be focusing on tackling the significant workload and economic problems dealing with GP practices, and supporting them … rather than wasting sources rearranging the NHS’s presently challenging bureaucracy.”


GP Michael Dixon, president of NHS Clinical Commissioners, which represents most CCGs, says their neighborhood and clinical understanding will be critical to support and handle long term NHS changes. “I can’t see why CCGs would be redundant,” he says.




Overall health thinktank urges further shakeup of GPs | Denis Campbell