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25 Temmuz 2016 Pazartesi

Tall story? Men and women have grown taller over last century, study shows

Men and women have grown taller over the last century, with South Korean women shooting up by more than 20cm (7.9in) on average, and Iranian men gaining 16.5 cm (6.5in). A comprehensive global study looked at the average height of 18-year old men and women in 200 countries between 1914 and 2014.


The results reveal that while Swedes were the tallest people in the world in 1914, Dutch men have risen from 12th place to claim top spot with an average height of 182.5cm (5ft 11.9 inches).


Latvian women, meanwhile, rose from 28th place in 1914 to become the tallest in the world a century later, with an average height of 169.8cm (5ft 6.9in).


With an increase in height seen across the century in every country around the world, the British have also gained a few inches. Both men and women have added around 11cm (4.3 in) to their height since 1914, with the average man now 177.5cm (5ft 9.8in) tall and the average woman boasting a height of 164.4cm (5ft 4.7in).


Mean height change since 1914 – women

James Bentham, a co-author of the research from Imperial College, London, says that the global trend is likely to be down primarily to improvements in nutrition, hygiene and healthcare. “An individual’s genetics has a big influence on [their] height … but once you average over whole populations genetics plays a less key [role],” he added. “Most populations would grow to roughly similar heights if they were all in the same conditions.”


A little extra height brings a number of advantages says Elio Riboli, co-author of the paper and director of the School of Public Health at Imperial College, London. “The good news is that being taller is associated with longer life expectancy,” he said. “This is largely due to a lower risk of dying of cardiovascular disease among taller people.” But, Riboli warns, while taller people have been found, on average, to have larger salaries and higher levels of education, there are downsides, with greater height potentially associated with an increased risk of some cancers.


The research was published in the journal eLife by the NCD Risk Factor Collaboration, a network of nearly 800 health scientists worldwide. The scientists drew on almost 1500 sources, including government health studies and military data, to model changes in the height of 18-year-olds across 200 countries over 100 years from 1914.


The results show that men are taller than women around the world, while for both sexes European countries now scoop the top 10 positions for height, with Dutch men and Latvian women the tallest for their sex. That, says Bentham, could be down to the introduction of a welfare state in many European countries.


By contrast, men from Timor-Leste are the shortest, with a height of 159.8cm (5ft 3in), while the title for shortest women remains with the female population of Guatemala, who have an average height of 149.4cm (4ft 10.8in).


But while height has increased around the world since the eve of the first world war, the researchers found that the degree of change varied greatly between countries.


Mean height change since 1914 – men

While South Korean women have shot up by just over 20cm (7.9 in) since 1914, men in South Africa have grown by just 1.4 cm (0.55 in) over the century. American men, meanwhile, have plateaued in height since the 1960s, resulting in a drop from third place in 1914 to 37th place in 2014. That, the authors suggest, could be down to worsening levels of nutrition and greater inequalities.


The trend in many countries of north and sub-Saharan Africa is also cause for concern says Riboli. While the research shows that height increased in countries such as Uganda and Niger during the early 20th century, the trend has reversed in recent years, with height decreasing among 18-year-olds.


“One reason for these decrease in heights in Africa is the economic situation in the 1980s,” said Alexander Moradi of the University of Sussex, who was not involved in the study. The nutritional and health crises that followed the policy of structural adjustment, he says, led to many children and teenagers failing to reach their full potential in terms of height. “I think one thing that one should keep in mind in these studies is that height is a useful indicator of how nutrition and health is developing and that these are closely related to the overall economic development [of a country], ” he added.


Bentham believes the global trend of increasing height has important ramifications. “How tall we are now is strongly influenced by the environment we grew up in. In turn, our height affects both our life expectancy and our health as adults,” he said. “If we give children the best possible start in life now, they will be healthier and more productive for decades to come.”



Tall story? Men and women have grown taller over last century, study shows

24 Ocak 2015 Cumartesi

DNA check set to reveal why space scientist is just 4ft tall


A room scientist who stopped increasing when he was just under 4ft tall is to turn out to be 1 of the very first individuals in Britain to have his whole genome sequenced below a ground-breaking new project to learn the secrets of DNA.




Michael Loweth and his family members will take portion in the Government’s new £300 million ’100,000 Genomes Project’, which seeks to discover the genetic cause behind mystery conditions.




Mr Loweth, a 37-12 months-old scientist and satellite engineer from Oxford, has in no way been given a diagnosis for his quick stature.




The two his mother and father had been tall, as was his sister, but he and his brother John had been noticeably smaller sized – foremost experts to feel that a faulty gene could be responsible.




Now, by getting not only his, but the total genomes of his loved ones sequenced, Mr Loweth could finally locate the answers he has been searching for all his life and find out if the genetic defect could influence his future kids.





“It will be the very first real possibility to uncover out what my genes will inform me about my very own issue of getting height restricted,” mentioned Mr Loweth.


“I have approached this as a scientist and engineer and I want to consider part since it might divulge secrets which will assist other folks.”


Clinics across the nation are taking component in the landmark venture which will sequence one hundred,000 genomes by 2017, a feat that has by no means been attempted on this kind of a scale, anyplace in the globe.


The DNA of a lot more than 75,000 men and women will be screened, as nicely as genetic make-up of 1000′s of tumours to locate the underlying mechanisms behind daily life threatening and debilitating illnesses.


David Cameron has said that the task will transform the potential of overall health care, major to new diagnostic exams and far better medication and remedies.


Mr Loweth was born in August 1977 at Basildon Hospital. His brother John who was eight at the time had also suffered from modest stature but professionals at Fantastic Ormond Street Hospital could not locate a result in.


His father Peter was 6ft 2ins and his late mother Helgamarie was 5ft 8ins. Medical professionals assured them there was just a one particular in 200 opportunity of the issue affecting later kids.


“But when I was born it was confirmed I had the exact same syndrome inside of half an hour,” explained Mr Loweth.


“It’s unusual due to the fact, if anything at all, I come from fairly a tall loved ones. My mothers and fathers in no way stated I was disabled or handled me any differently, but we all get handed cards and some are more obvious than other people.


“I have in no way had a diagnosis and I was advised that if I needed to find out what was incorrect I would have to go down a genetic route. This should bring my the solutions that I am looking for.”



Michael with his dad Peter, brother John and sister Vicky Houghton (Julian Andrews/The Telegraph)


To help scientists appear for the fault in Mr Loweth’s genome, they will also be sequencing the DNA of his father, sister and brother so they can evaluate the genetic code and appear for abnormalities. The final results are expected in the Spring.


Father Peter said: “We were suggested initially that the probability of repeating John’s problem was one in four, this was later relaxed to one in 200 and then following about five many years we have been told that there was very minor chance of a repartition.


“Eight many years soon after John was born Michael arrived. I was present at the birth and asked the sister in charge if all was nicely and explained about his brother.


“The sister named up the senior advisor. Realizing all about John she carefully examined Michael with the comment “I consider you have completed it once again.”


Experts have speculated that his syndrome could by a sort of spondylo-epiphyseal dysplasia, which can result in shortened limbs.


The issue has prevented Mr Loweth training to turn into an astronaut, although he has worked for NASA. He graduated in BEng in Aerospace Engineering from Kingston University in 2000 and a masters degree in Room Research in Strasbourg, France. He is ready to drive, has skydived and is understanding to fly.


“I have realized to cope with,” said Mr Loweth, who now works on satellites at ABSL Room Merchandise in Abingdon, Oxfordshire. “You can appear at things in two methods, optimistic or damaging.


“I can’t get a suit that will fit off the shelf but I have been in rowing teams- as the cox – at Henley and in a nationwide championship and internationally like in the US.


“I can now perform my part in currently being an additional piece of the jigsaw that tends to make the genome task yield answers for other people’s healthcare. That has acquired to be a step in the appropriate path.”


Professor Mark Cauldfield, Chief Scientist at Genomics England, explained: “The 100,000 Genomes Project aims to supply new genomic diagnoses for individuals with uncommon disorders like this one here. We also aim to obtain insights into how we can much better target medicines in cancer care and in infection we hope the programme will generate new opportunities for therapies.”


Since the whole genome is currently being sequenced volunteers can make a decision how much info they acquire. Some might only want to learn about the certain illness they are becoming screened for, but others could want to know more about their make-up and chance of developing other disease.


Mr Loweth is keen to find out everything that his DNA can reveal.


“Some individuals say ignorance is bliss but I want to know and – if it displays that there are other concerns for me to have to deal with – nicely I will do that. I see, as a scientist, that there should be an answer,” mentioned Mr Loweth.


“I don’t have any true worry about locating out more about myself. Why wouldn’t I want to know?”


On Thursday the Royal Institution will be internet hosting a debate on the long term of DNA in healthcare. The Astellas Innovation Debate 2015: i-Genes – What the DNA and Information Revolutions suggest for our Well being will be streamed dwell from 6.30pm at www.innovationdebate.com





DNA check set to reveal why space scientist is just 4ft tall