Doses etiketine sahip kayıtlar gösteriliyor. Tüm kayıtları göster
Doses etiketine sahip kayıtlar gösteriliyor. Tüm kayıtları göster

18 Ocak 2014 Cumartesi

Hgh Doses of Omega EPA Saves Hit & Run Victim in Coma

Very first reported by CNN — It was mild curiosity that drew John Virgin and his son Bryce to the flashing lights and commotion of an accident scene near their residence.


In the back of John’s thoughts was his older son, Grant, who had gone for a stroll close by minutes earlier.  John looked down at the area that had been cordoned-off — the pavement covered with blood — and his heart sank.


“At that level you realize your worst fear,” he said. “I knew it was grave.”


Minutes earlier, the 16-12 months-previous had been airlifted to a nearby trauma center following being struck by a hit-and-run driver. He had a extended checklist of injuries: a torn aorta, a traumatic brain injury — like skull fractures and bleeding throughout his brain — compound bone fractures and spinal fractures. Seemingly countless bits of broken glass and gravel had been embedded in his skin


When they arrived, they were met by grim-faced doctors who supplied the slimmest odds that Grant Virgin would reside via the evening.


From that second forward — time and time yet again — they would go against doctor’s orders. That included attempting unconventional, untested therapies — something that may assist Grant. One particular in distinct involved offering him high doses of omega-three fatty acids (discovered in phytoplankton).


Fish oil is what the Virgin family members believes eventually — significantly — altered his daily life program, and healed his brain.


Weeks before fish oil was even regarded, Grant Virgin underwent a number of surgeries, and spent considerable time on a ventilator.


Ultimately, his body was stable, but his brain was nevertheless riddled with damage. He was in a coma, and his medical professionals urged his household to “wait and see” although his brain healed.


“The physician told me, ‘OK, now we wait.’ and I go, ‘We wait?’ ‘Yes, we wait,’” said JJ Virgin, who questioned that program of action — “‘Surely there’s one thing we can do?’”


The doctor’s response, according to her: “‘Nope, there’s absolutely nothing we can do. We just wait. The brain’s got its own time routine.’”


About the same time, she was receiving a flurry of suggestions from close friends. One suggested attempting progesterone to heal her son’s brain.


In early research, progesterone has been linked with decreased irritation in the brain and improved neurological outcomes right after traumatic brain damage. But the data in this spot, despite the fact that promising, are extremely early.


Despite that, beginning about two weeks right after the accident, his mom and father started intermittently rubbing a cream containing progesterone on him. (A leading professional questioned the efficacy of administering progesterone in this way, noting that in studies, it is administered intravenously.)


JJ Virgin received far more guidance, this time from close friends who had observed a CNN report about large-dose fish oil used in cases of serious traumatic brain injury.


Fish oil, they imagined, may heal Grant Virgin’s brain.


“If somebody said to me, you know what, you can give him fish oil, you can give him far better nutrition, you’ll get perhaps five% (improvement), I’ll consider that,” she explained.


She acquired in touch with one particular of the foremost omega-3 experts, Dr. Barry Sears, who had consulted on the initial-ever case of large-dose fish oil for traumatic brain injury in 2006.


It concerned a miner, Randal McCloy, who was involved in a deadly explosion in West Virginia. His brain had been badly damaged by carbon monoxide, and his staff of medical doctors was attempting desperately to hold him alive.


McCloy’s neurosurgeon at the time, Dr. Julian Bailes, describes thinking about substantial-dose fish oil in this situation, as akin to “throw(ing) the kitchen sink at him.”


“There is no recognized remedy, there’s no acknowledged drug, there’s absolutely nothing that we have actually to supply these sorts of patients,” mentioned Bailes, co-director of NorthShore Neurological Institute in Evanston, Illinois, throughout a preceding interview with CNN.


The theory behind fish oil as a therapeutic intervention for traumatic brain injury is at after easy and complicated.


Basically stated, the brain’s cell wall is, in portion, composed of omega-three fatty acids.


“If you have a brick wall and it will get damaged, wouldn’t you want to use bricks to fix it?” mentioned Dr. Michael Lewis, founder of the Brain Health Schooling and Investigation Institute. “By supplementing using (omega-three fatty acids) in significant doses, you give the basis for the brain to restore itself.”


Much more difficult is how omega-3 fatty acids may manage irritation — or injury — in the brain. Sears likens it to quelling a metaphorical fire in the brain.


That “fire” commences when the brain is traumatized — as with a profound injury like Grant Virgin’s, or milder insults like concussions suffered on a soccer field. Neurons snap, setting off a wave of irritation in the brain that can smolder for prolonged intervals of time — sometimes weeks or months soon after the damage has occurred.


“That (inflammation) will carry on more than and more than except if there is a 2nd response that turns it off,” explained Sears, president of the Irritation Analysis Foundation.


The fatty acid that Sears says can properly “turn off” that inflammatory fire is a metabolite (what remains after the entire body breaks one thing down) of eicosapentaenoic acid, or EPA, referred to as resolvin.


EPA is identified in substantial concentrations of phytoplankton, which is eaten by fish that absorb its nutrients.


“What we feel is taking place is, large amounts of EPA coursing in the brain metabolize into resolvins, turning down and turning off inflammatory method,” explained Sears.


Taking into consideration that, in accordance to the Centers for Illness Control and Prevention, one.seven million traumatic brain injuries arise in the United States each year, any intervention — particularly a inexpensive one particular like fish oil — is an fascinating prospect.


But Omega-three as a viable and effectively-studied intervention is still a approaches off for now it dwells in the realm of the anecdote or case research.


And a situation similar to Grant Virgin’s: a teenager named Bobby Ghassemi who nearly died in a car accident prior to obtaining a massive infusion of fish oil. A couple of months later, he attended his high school graduation.


There was the case of an 8-yr-old woman who nearly drowned after her stroller rolled into a canal. Her head and face had been beneath water for far more than 5 minutes.


Eighty-two days soon after her accident, in accordance to a case review published last yr in the journal PharmaNutrition, she was provided substantial doses of omega-three fatty acids, soon after which, “…the patient exhibited extremely gradual but steady progress in terms of her tolerance for stimulation and action.”


Jordan Markuson is the Founder of Aqua Wellness Labs.  He has been a nutritionist and entrepreneur for over ten years.  He is an activist supporting consumption of raw greens and consuming only renewable, normal and natural meals.  Jordan believes that based on all accessible scientific proof,  when meals is cooked it loses the majority its essential nutrients.   He is really interested in marine based mostly foods since of the crucial fatty acids they produce nowhere else on earth.



Hgh Doses of Omega EPA Saves Hit & Run Victim in Coma

16 Ocak 2014 Perşembe

FDA Warns High Doses of Acetaminophen Can Lead To Liver Damage


Open bottles of Extra Strength Tylenol and Ext...

(Photograph credit score: Wikipedia)




The FDA has just issued a statement urging medical doctors not to prescribe acetaminophen in doses greater than 325 mg. Liver injury has been a known risk of the drug for many years, with even low doses posing serious dangers in excess of the prolonged-term. One more issue, however, is substantial doses in the quick-term, which can be a distinct danger if men and women aren’t mindful that they’re taking numerous acetaminophen-containing medicines. For illustration, prescription drugs, like oxycodone (Percocet), codeine, and hydrocodone (Vicodin) all include acetaminophen, so folks might unwittingly give themselves a double-dose by popping a Tylenol while already one of these prescription meds. And this, the FDA says, has to quit.


“Many customers are usually unaware that many goods (each prescription and OTC) contain acetaminophen, creating it straightforward to accidentally take also much,” mentioned the FDA.


Acetaminophen poisoning is one of the most widespread types of drug toxicity in the world, according to the NIH.


Acetaminophen can cause liver injury since the organ processes any compound that passes by means of. In the case of acetaminophen, a byproduct of its breakdown, NAPQI, can create up and significantly damage the liver’s own cells.


Because of these hazards, which far overshadow the positive aspects of the drug, the FDA says it is time to limit the dosage in prescriptions. “There are no available data to present that taking much more than 325 mg of acetaminophen per dosage unit supplies further advantage that outweighs the additional dangers for liver injury.”


In accordance to the FDA, folks at risk of liver damage consist of people who:



  • “took much more than the prescribed dose of an acetaminophen-containing product in a 24-hour period”

  •  “took a lot more than one acetaminophen-containing item at the identical time”

  • “drank alcohol even though taking acetaminophen products.”


The early symptoms of liver damage are typically vague and include loss of appetite, nausea, and vomiting, and can initially mistaken for other ailments, like the flu. More severe signs and symptoms incorporate stomach discomfort, convulsions, diarrhea, irritability, jaundice, and coma. “Liver harm can produce into liver failure or death above a number of days,” says the FDA.


The suggested optimum everyday limit is 4,000 mg, which is the sum in just four Additional Strength Tylenol. Over seven,000 mg/day is sufficient to result in serious overdose, according to the NIH.


To decrease the threat of liver injury, the FDA advises individuals to:



  • Usually comply with dosing instructions and by no means get much more than indicated, since “even a modest sum far more than directed can lead to liver damage.”

  • Don’t get acetaminophen for longer than directed.

  • Don’t get a lot more than one acetaminophen-containing medication at a time.


For example, “your danger of liver harm goes up if you consider a medicine that contains acetaminophen to treat a headache, and while that medication is still operating in your physique, you take yet another medicine that includes acetaminophen to treat a cold,” according to the FDA.


The FDA will handle over-the-counter (OTC) acetaminophen in a separate statement. Once more, because cold and flu prescription drugs frequently have acetaminophen, it is exceptionally essential to examine the ingredients in any OTC medicine you consider, so that you really do not unwittingly double up. And often keep away from alcohol whilst you’re taking items containing acetaminophen, considering that the mixture of alcohol and acetaminophen can place your liver at especially substantial danger.


For much more information, please see the FDA’s web site on acetaminophen toxicity.



FDA Warns High Doses of Acetaminophen Can Lead To Liver Damage